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FLASH GENE
Symbol DPF3 contributors: mct - updated : 09-05-2018
HGNC name D4, zinc and double PHD fingers, family 3
HGNC id 17427
Location 14q24.2      Physical location : 73.136.659 - 73.360.809
Synonym name
  • neuro D4, zinc finger-like structural motif 2
  • cer-d4 homolog
  • zinc finger protein DPF3
  • BRG1-associated factor 45C
  • zinc finger protein cer-d4
  • Synonym symbol(s) CERD4, FLJ14079, ND4ZNF2, 2810403B03Rik, BAF45C
    DNA
    TYPE functioning gene
    STRUCTURE 224.15 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure downstream target of Mef2a
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387997 14 LOC387997 LOC390492 14 similar to GWSC6486 SIPA1L1 14q24.1 signal-induced proliferation-associated 1 like 1 RGS6 14q24.3 regulator of G-protein signalling 6 DPF3 14q24.3-q31.1 D4, zinc and double PHD fingers, family 3 WDR21 14q24.3 WD repeat domain 21 RPL36AP3 14 ribosomal protein L36a pseudogene 3 RPS12P1 14 ribosomal protein S12 pseudogene 1 ZFYVE1 14q22-q24 zinc finger, FYVE domain containing 1 RNPC7 14q24.3 RNA-binding region (RNP1, RRM) containing 7 PSEN1 14q24.3 presenilin 1 (Alzheimer disease 3) PAPLN 14q24.2 papilin, proteoglycan-like sulfated glycoprotein NUMB 14q24.3 numb homolog (Drosophila) C14orf169 14q24.2 chromosome 14 open reading frame 169 NT5CP2 14q24.2 5',3'-nucleotidase, cytosolic pseudogene 2 ZAP128 14q24.3 5',3'-nucleotidase, cytosolic pseudogene 2 NT5CP1 14q24.2 5',3'-nucleotidase, cytosolic pseudogene 1 PTE2B 14q24.2 peroxisomal acyl-CoA thioesterase 2B C14orf42 14q24.1 chromosome 14 open reading frame 42 NDUFB8P1 14 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, pseudogene 1 C14orf168 14q24.3 chromosome 14 open reading frame 168 PNMA1 14q24.2 paraneoplastic antigen MA1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2271 - 357 restricted to the myocardial compartment of the heart 2008 18765789
    C-terminal double PHD is truncated in DPF3a
    - splicing 1138 - 378 - 2008 18765789
  • also called DPF3b
  • differ at the C terminus such that DPF3a encodes a 357-amino-acid protein containing a single truncated PHD finger, while DPF3b consists of 378 amino acids and a double PHD finger
  • pecific binding to acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac) besides binding to mono- and dimethylated Lys 4 on histone 3 (H3K4me1/2)
  • EXPRESSION
    Rna function restricted to heart and skeletal muscle
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Nervousbrainhindbraincerebellum   Homo sapiens
    Visualeyeretina  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly Homo sapiens
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    Nervousoptic nerve Homo sapiens
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal 2/3 domain unique to this protein family, a highly-conserved N-terminal 84-AA region (designated "CT1") can function as an efficient dominant-negative mutant of the entire d4-family proteins
  • a double PHD finger, interacting with acetylated as well as methylated histone tail residues, namely acetylated lysines on histones 3 and 4
  • a C2H2-type zinc finger
  • a C-terminal PHD zinc finger
  • HOMOLOGY
    interspecies homolog to murine Cerd4
    intraspecies homolog to NEUROD4
    Homologene
    FAMILY
  • requiem/d4 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be having an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor
  • potentially serves as an anchor between the BAF complex and modified histones
  • DPF1, DPF2, DPF3 function as adaptor proteins linking NFKB1 with the SWI/SNF complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and
  • interaction with SMARCD3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the right ventricular myocardium of patients with Tetralogy of Fallot (TOF)
    Susceptibility to breast cancer development
    Variant & Polymorphism other Polymorphisms in the 5' region of DPF3 were associated with increased risk of breast cancer development, lymph node metastases, age of onset, and tumor size in women of European ancestry
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS