basic FUNCTION
| involved in rapid growth and cell turnover |
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may be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells |
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might also have a role in the development and maturation of lymphoid cells |
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adaptor molecule that links the NF-kappaB and SWI/SNF chromatin remodeling factor |
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functions as an efficient adaptor protein between the SWI/SNF complex and RELB and plays important roles in noncanonical NF-kappaB transcriptional activation and its associated oncogenic activity |
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acts as a nuclear receptor-selective co-repressor for ESRRRA by associating with both acetylated histone H3 and HDAC1 |
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its recruitment may change the state of chromatin conformation by converting acetylated histones into inactive, deacetylated histones |
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may potentially recruit an HDAC co-repressor complex to achieve transrepression through chromatin remodeling mediated by the SWI/SNF complex |
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SMARCA4, SMARCD2, DPF2 are required for the expression of haematopoietic stem cell associated genes but in contrast to previous results obtained in mouse cells, the three proteins are not required for the expression of MYC regulated genes |
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histone binding of DPF2 plays an important regulatory role in the transcriptional program that drives myeloid differentiation |
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DPF1, DPF2, DPF3 function as adaptor proteins linking NFKB1 with the SWI/SNF complex |
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presumably functions as an apoptotic factor, especially during the deprivation of trophic factors |