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FLASH GENE
Symbol DPF2 contributors: np/mct - updated : 11-04-2018
HGNC name D4, zinc and double PHD fingers family 2
HGNC id 9964
Corresponding disease
CSSS8 Coffin-siris syndrome 8
Location 11q13.1      Physical location : 65.101.345 - 65.120.450
Synonym name
  • neuro D4
  • requiem, apoptosis response zinc finger gene
  • apoptosis response zinc finger protein
  • BRG1-associated factor 45D
  • zinc finger protein ubi-d4
  • Synonym symbol(s) REQ, UBID4, MGC10180, ubi-d4
    DNA
    TYPE functioning gene
    STRUCTURE 20.51 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located between MLK3 and FAU, at 150kb from MLK3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2411 45 391 - 2006 17081983
    12 - 3897 - 405 - 2006 17081983
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrinethyroid   highly
    Reproductivefemale systemuterus   
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • highly-conserved N-terminal 84-AA region (designated "CT1") can function as an efficient dominant-negative mutant of the entire d4-family proteins
  • a C2H2-type Kruppel-like zinc finger domain, a C4HC3-type double PHD fingers domain (d4 domain), and the tandem PHD finger of DPF2 is also responsible for the epigenetic regulation of transcription through the identification of rare histone modifications such as propionylation, butyrylation
  • HOMOLOGY
    interspecies homolog to murine gene ubi d4 (ubiquitous)
    homolog to to C. elegans Dpff-1
    intraspecies paralog to DPF3
    Homologene
    FAMILY
  • requiem/DPF family
  • d4-family protein
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in rapid growth and cell turnover
  • may be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells
  • might also have a role in the development and maturation of lymphoid cells
  • adaptor molecule that links the NF-kappaB and SWI/SNF chromatin remodeling factor
  • functions as an efficient adaptor protein between the SWI/SNF complex and RELB and plays important roles in noncanonical NF-kappaB transcriptional activation and its associated oncogenic activity
  • acts as a nuclear receptor-selective co-repressor for ESRRRA by associating with both acetylated histone H3 and HDAC1
  • its recruitment may change the state of chromatin conformation by converting acetylated histones into inactive, deacetylated histones
  • may potentially recruit an HDAC co-repressor complex to achieve transrepression through chromatin remodeling mediated by the SWI/SNF complex
  • histone binding of DPF2 plays an important regulatory role in the transcriptional program that drives myeloid differentiation
  • DPF1, DPF2, DPF3 function as adaptor proteins linking NFKB1 with the SWI/SNF complex
  • presumably functions as an apoptotic factor, especially during the deprivation of trophic factors
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • having a co-repressor function for ESRRA
  • together with SMARCA2, a catalytic subunit of the SWI/SNF complex, enhances the NF-kappaB-dependent transcriptional activation that principally involves the RELB dimer
  • DPF2 decreases monomeric and mono-ubiquitinated POU5F1, assembles poly-ubiquitin chains on POU5F1 mainly through Ub-K48 linkage
  • DPF2, also named ubi-d4/requiem (REQU), interacts with a protein complex containing POU5F1
  • interacts with the acetylated tails of both histones 3 and 4 via bipartite binding pockets on the DPF2 surface
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSSS8
    Susceptibility
    Variant & Polymorphism
    Candidate gene for multiple endocrine neoplasia type I (inherited cancer syndrome involving multiple parathyroid, pancreatic and pituitary tumors)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • dpff-1 deficient animals are more sensitive to heat shock