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FLASH GENE
Symbol DPF1 contributors: mct/npt - updated : 09-05-2018
HGNC name D4, zinc and double PHD fingers family 1
HGNC id 20225
Location 19q13.13      Physical location : 38.701.649 - 38.720.317
Synonym name neuro D4, zinc finger-like structural motif 1
Synonym symbol(s) ND4ZNF1, NEUD4, neuro-d4, BAF45b, MGC150428, MGC150429
DNA
TYPE functioning gene
STRUCTURE 18.67 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 splicing 2329 - 414 - Chestkov (1996)
12 splicing 2306 - 332 - Chestkov (1996)
11 - 2227 - - - Chestkov (1996)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   moderately Homo sapiens
 nerve     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text predominantly expressed in the developing brain (Lange 2008)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • highly-conserved N-terminal 84-AA region (designated "CT1") can function as an efficient dominant-negative mutant of the entire d4-family proteins
  • zinc finger-like structural motif/two PHD-type zinc fingers
  • HOMOLOGY
    interspecies ortholog to murine Neud4
    homolog to rattus Neud4
    Homologene
    FAMILY
  • requiem/DPF family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in induction of apoptosis
  • having an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor
  • DPF1, DPF2, DPF3 function as adaptor proteins linking NFKB1 with the SWI/SNF complex
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS