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FLASH GENE

Symbol

DPF1

contributors: mct/npt - updated : 09-05-2018

HGNC name	D4, zinc and double PHD fingers family 1
HGNC id	20225

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.13      Physical location : 38.701.649 - 38.720.317
Synonym name	neuro D4, zinc finger-like structural motif 1
Synonym symbol(s)	ND4ZNF1, NEUD4, neuro-d4, BAF45b, MGC150428, MGC150429

DNA

TYPE	functioning gene
STRUCTURE	18.67 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001135155 12 splicing 2329 NP_001128627 - 414 - Chestkov (1996) NM_001135156 12 splicing 2306 NP_001128628 - 332 - Chestkov (1996) NM_004647 11 - 2227 - - - Chestkov (1996)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       moderately Homo sapiens   nerve         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

Text	predominantly expressed in the developing brain (Lange 2008)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	highly-conserved N-terminal 84-AA region (designated "CT1") can function as an efficient dominant-negative mutant of the entire d4-family proteins
	zinc finger-like structural motif/two PHD-type zinc fingers

HOMOLOGY

interspecies	ortholog to murine Neud4
	homolog to rattus Neud4

Homologene

FAMILY

requiem/DPF family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in induction of apoptosis
	having an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor
	DPF1, DPF2, DPF3 function as adaptor proteins linking NFKB1 with the SWI/SNF complex

CELLULAR PROCESS	cell life, cell death/apoptosis
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma DPF1 is a potential therapeutic targets for glioblastoma

ANIMAL & CELL MODELS