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FLASH GENE

Symbol

DPEP2

contributors: mct - updated : 28-03-2019

HGNC name	dipeptidase 2
HGNC id	23028

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q22.1      Physical location : 68.021.294 - 68.033.364
EC.number	3.4.13.19

DNA

TYPE	functioning gene
STRUCTURE	13.25 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001324159 9 - 1273 NP_001311088 - 328 - 2003 12738806 NM_022355 11 - 1728 NP_071750 - 486 - 2003 12738806

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Lymphoid/Immune spleen       moderately Homo sapiens Reproductive female system uterus         male system testis     highly Homo sapiens Respiratory lung       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

secondary structure

disulfide-linked

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Dpep2

Homologene

FAMILY

peptidase family M19

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	GPI-anchored

basic FUNCTION	hydrolyzes a wide range of dipeptides
	implicated in the renal metabolism of glutathione and its conjugates
	converts leukotriene d4 to leukotriene e4; it may play an important role in the regulation of leukotriene activity
	cleaves leukotriene D4 (LTD4) but not cystinyl-bis-glycine
	DPEP2 could protect against Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) by acting as a suppressor of macrophage inflammation

CELLULAR PROCESS	protein, post translation
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	zinc Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS