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FLASH GENE
Symbol DPEP1 contributors: mct - updated : 28-03-2019
HGNC name dipeptidase 1 (renal)
HGNC id 3002
Location 16q24.3      Physical location : 89.679.715 - 89.704.838
Synonym symbol(s) RDP, MDP, MBD1
EC.number 3.4.13.19
DNA
TYPE functioning gene
STRUCTURE 28.23 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Physical map
LOC388308 16 similar to Brain-type organic cation transporter FLJ31875 16q24.3 hypothetical protein FLJ31875 ANKRD11 16q24.3 ankyrin repeat domain 16 LOC390750 16 similar to Hypothetical protein CBG22662 LOC390751 16 LOC390751 SPG7 16q24.3 spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) RPL13 16q24.3 ribosomal protein L13 CPNE7 16q24.3 copine VII DPEP1 16q24.3 dipeptidase 1 (renal) PCOLN3 16q24.3 procollagen (type III) N-endopeptidase FLJ31606 16q24.3 hypothetical protein FLJ31606 LOC388309 16 LOC388309 CDK10 16q24.3 cyclin-dependent kinase (CDC2-like) 10 MGC26885 16q24.3 hypothetical protein MGC26885 C16orf7 16q24 chromosome 16 open reading frame 7 ZFP276 16q24.3 zinc finger protein 276 homolog (mouse) FANCA 16q24.3 Fanconi anemia, complementation group A LOC197317 16q24.3 hypothetical LOC197317 Spir-2 16q24 Spir-2 protein KIAA1049 16q24.3 Spir-2 protein FLJ12547 16q24.3 hypothetical protein FLJ12547 MC1R 16q24.3 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) TUBB4 16q24.3 tubulin, beta, 4 FLJ20186 16q24.3 hypothetical protein FLJ20186 MGC13198 16q24.3 hypothetical protein MGC13198 MGC16385 16q24.3 hypothetical protein MGC16385 AFG3L1 16q24 AFG3 ATPase family gene 3-like 1 (yeast)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1664 - 411 - 2002 12144777
11 - 1752 - 411 - 2002 12144777
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Hearing/Equilibriumear   predominantly Homo sapiens
Respiratorylung     Homo sapiens
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion sreum, urine
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal signal peptide, a 22-amino acid signal peptide
  • four potential N-glycosylation sites
  • a GPI-acnhor
  • a C-ter propeptide removed in the mature form
  • secondary structure eight alplha helix and beta sheet pairs per subunit
    conjugated GlycoP , LipoP , MetalloP
    mono polymer homomer , dimer
    isoforms Precursor a signal peptide from the 1st to the 16th aa
    HOMOLOGY
    Homologene
    FAMILY peptidase M19 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • attached to the membrane by a GPI-anchor
  • brush border membrane
  • basic FUNCTION
  • hydrolyzing a wide range of dipeptides
  • playing an important role in the regulation of leukotriene activity
  • converting lekotriene D4 to leukotriene E4
  • plays a role in pancreatic cancer aggressiveness
  • functions as a positive regulator for colon cancer cell metastasis
  • zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    metabolism of glutathione and its conjugates
    a component homodimer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    two ions Zn2+
    protein
  • DPEP1 promotes cancer metastasis by regulating CDH1 plasticity
  • cell & other
    REGULATION
    inhibited by by EEDQ and dansyl-ethylenediamine
    cilastatin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers (CRCs) and high DPEP1 expression levels are associated with poorer patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • excellent marker of high-grade intraepithelial neoplasia (IEN) and Colorectal cancer (CRC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    it might be a potential therapeutic target for preventing the progression of colon cancer
    cancerendocrinepancreas
    DPEP1 may be a candidate target in PDAC for designing improved treatments
    ANIMAL & CELL MODELS
    Mbd1 deficient mice