| basic FUNCTION
| playing a role in nucleosomal histone methylation |
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methylating Lys-79 of histone H3 |
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recruitment important for transformation by the MLL-MLLT1 fusion derivative  |
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can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia |
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through H3K79 methylation play important roles in heterochromatin formation and in embryonic development |
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a unique histone methyltransferase that specifically methylates histone H3 at lysine 79 |
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DOT1L-dependent H3K79 methylation serves as a critical regulator of a differentiation switch during early hematopoiesis |
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involved in the regulation of telomeric silencing, development, cell cycle checkpoint and transcription |
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might control AF9- and ENL-mediated transcription, regulate RNA processing, and function as a histone chaperone in a NPM1-dependent manner |
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responsible for methylation of histone H3 at lysine 79 and is involved in the pathobiology of several leukemias, the majority of which are characterized by chromosomal translocations involving the mixed lineage leukemia (MLL) gene |
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may contribute to euchromatin formation or transcription |
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DOT1L-dependent lysine 79 of histone H3 methylation serves potentially as a critical regulator of a differentiation switch during early hematopoiesis |
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critical role for DOT1L-mediated H3K79 methylation in cardiomyocyte function |
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MLLT10/AF10 and DOT1L are essential activators to a large extent dedicated to Wnt target gene regulation |
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H3K79 methyltransferase, required for both initiation and maintenance of MLL-AF9-induced leukemogenesis |
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DOT1L participates in the regulation of transcription, development, erythropoiesis, differentiation, and proliferation of normal cells |
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DOT1L promotes the formation of the pre-initiation complex on the promoters of UV-repressed genes and the appearance of transcriptionally active chromatin marks |
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DOT1L secures likely an open chromatin structure in order to reactivate RNA Pol II transcription initiation after a genotoxic attack |
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is involved in a number of key processes ranging from gene expression to DNA-damage response and cell cycle progression |
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essential role for DOT1L in generating an effective humoral immune response |
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combination of SIRT1 activators and DOT1L inhibitors shows enhanced antiproliferative activity against KMT2A-rearranged leukemia cells |
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promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex |
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role for the histone H3K79 methyltransferase DOT1L in controlling B-cell differentiation |
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DOT1L is a key modulator of the core transcriptional and epigenetic landscape in B cells, establishing an epigenetic barrier that warrants B-cell naivety and GC B-cell differentiation |
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DOT1L is an epigenetic regulator of the senescence-associated secretory phenotype (SASP), whose expression is uncoupled from the senescence-associated cell cycle arrest |
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DOT1L protects against osteoarthritis, and DOT1L-mediated H3K79 methylation is reduced in human osteoarthritic joints |
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is the sole H3K79 methyltransferase, and required for spermatogonial stem cell self-renewal |
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essential function for DOT1L in adult stem cells and likely involved regulation of spermatogonial stem cells |
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has a specialized role in transcription of major satellite repeats to maintain pericentromeric heterochromatin and genome stability |
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important role for DOT1L as a bridge between transcriptional activation of repeat elements and heterochromatin stability |
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methylates a lysine residue (K79) in the core globular domain of histone H3 |
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is a conserved H3K79 methyltransferase |
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DOT1L acts in a distributive manner such that it can only sequentially add methyl groups to each H3K79 residue |
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