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FLASH GENE
Symbol DONSON contributors: KTN/npt - updated : 05/11/2008
HGNC name downstream neighbor of SON
HGNC id 2993
Location 21q22.1      Physical location : 34.950.211 - 34.961.014
Synonym name
  • chromosome 21 open reading frame 60
  • MHC class II transactivator type I
    • Synonym symbol(s) C21orf60, B17, C2TA, DKFZp434M035
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation, tail to tail
    text
  • in tail-to-tail orientation with SON
    • STRUCTURE 10.80 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see IFNAR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2189 62.6 566 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   predominantly
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland moderately
    Urinarybladder   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to dog DONSON (86.4 pc)
    homolog to chimpanzee DONSON (99.3 pc)
    homolog to cow DONSON (87.3 pc)
    homolog to rattus Donson (79.5 pc)
    homolog to murine Donson (78 pc)
    Homologene
    FAMILY
  • DONSON family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an essential role for DNA amplification in the ovary
  • required for cell proliferation during development
  • acting as a transcription repressor
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • multicellular organismal development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS