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FLASH GENE
Symbol DOK6 contributors: - updated : 03-04-2006
HGNC name docking protein 6
HGNC id 28301
Location 18q22.2      Physical location : 67.068.283 - 67.516.320
Synonym name
  • docking protein 5-like
  • downstream of tyrosine kinase 6
  • Synonym symbol(s) MGC20785, HsT3226, DOK5L
    DNA
    TYPE functioning gene
    STRUCTURE 441.00 kb     8 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a IRS-type PTB domain mediating receptor interaction
  • a PH domain
  • HOMOLOGY
    Homologene
    FAMILY DOK family, type B subfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • promotes Ret- mediated neurite growth
  • may have a role in brain development and/or
  • maintainance
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts via its PTB domain with phosphorylated RET
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other aphidicolin-inducible fragile site
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS