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FLASH GENE
Symbol DOK5 contributors: - updated : 16-04-2005
HGNC name docking protein 5
HGNC id 16173
Location 20q13.2      Physical location : 53.092.265 - 53.267.709
Synonym name
  • downstream of tyrosine kinase 5
  • chromosome 20 open reading frame 180
  • Synonym symbol(s) dJ805C22.1, MGC16926, C20orf180, IRS6
    DNA
    TYPE functioning gene
    STRUCTURE 175.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPS33P4 20q13.13 mitochondrial ribosomal protein S33 pseudogene 4 RPL36P1 20q13 ribosomal protein L36 pseudogene 1 C20orf17 20q13.2 chromosome 20 open reading frame 17 PPIAL2 20q13.2-q13.3 peptidylprolyl isomerase A (cyclophilin A)-like 2 ZNF217 20q13.2 zinc finger protein 217 LOC391257 20 similar to Chain  , Structure Determination Of The Small Ubiquitin-Related Modifier Sumo-1, Nmr, 10 Structures BCAS1 20q13.2 breast carcinoma amplified sequence 1 CYP24A1 20q13.2-q13.3 cytochrome P450, family 24, subfamily A, polypeptide 1 PFDN4 7p22 prefoldin 4 DOK5 20q13.2 docking protein 5 RPL12P4 20q13.2 ribosomal protein L12 pseudogene 4 CBLNL1 20q13.13-q13.33 cerebellin precursor-like 1 MC3R 20q13.2-q13.3 melanocortin 3 receptor C20orf108 20q13.2 chromosome 20 open reading frame 108 STK6 20q13.31 serine/threonine kinase 6 CSTF1 20q13.2-q13.3 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa C20orf32 20q13.31 chromosome 20 open reading frame 32 RPL39P 20q13.2 ribosomal protein L39 pseudogene C20orf43 20q13.31 chromosome 20 open reading frame 43 C20orf106 20q13.2 chromosome 20 open reading frame 106 LOC388799 20 similar to dJ1153D9.4 (novel protein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1851 35 306 - Cai
    longer isoform
    - - 1752 - 198 - Cai
    differs in the 5'UTR and coding region resulting in a shorter isoform compared to variant 1
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Nervousbrain   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage activated T cells only
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • pleckstrin homology domain and PTB domains at the N-terminus
  • a short C terminus with 3 potential sites for tyrosine phosphorylation
  • HOMOLOGY
    interspecies ortholog to murine Dok5
    intraspecies homolog to DOK4
    Homologene
    FAMILY DOK family
    CATEGORY adaptor , signaling , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • potential roles in insulin and IGF-1 action
  • may be involved in the regulation of the immunse response induced by T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway
  • signaling proteins with potential roles in insulin and IGF-1 action
  • cell & other
    REGULATION
    Other tyrosine-phosphorylated in response to insulin and IGF-1
    regulated upon T cell activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS