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FLASH GENE
Symbol DOCK9 contributors: mct - updated : 09-03-2011
HGNC name dedicator of cytokinesis 9
HGNC id 14132
Location 13q32.3      Physical location : 99.445.740 - 99.738.660
Synonym name
  • rat TRG protein homolog
  • zizimin 1
  • Synonym symbol(s) KIAA1058, ZIZ1, zizimin1, DKFZp686C11110, DKFZp686D2047, DKFZp686N04132, FLJ11949, FLJ16744, FLJ44528, FLJ45282, FLJ45601, KIAA1058, KIAA1085
    DNA
    TYPE functioning gene
    STRUCTURE 292.92 kb     61 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    HS6ST3 13 heparan sulfate 6-O-sulfotransferase 3 LOC283476 13q32.2 hypothetical protein LOC283476 LOC390420 13 similar to heat shock protein 84 - mouse LOC341592 13q32.2 similar to tubby like protein 3 GPR80 13q32.2 G protein-coupled receptor 80 MBNL2 13q31.1 muscleblind-like 2 (Drosophila) RAP2A 13q34 RAP2A, member of RAS oncogene family LOC121906 13q32.2 similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (27 kDa prosomal protein) (PROS-27) (p27K) LOC387943 13 LOC387943 KPNB3 13q32.2 karyopherin (importin) beta 3 FARP1 13q32.2-q32.3 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) ZNF183L1 13q zinc finger protein 183-like 1 STK24 13q32 serine/threonine kinase 24 (STE20 homolog, yeast) HCP35 13q32.3 cytochrome c, somatic pseudogene SLC15A1 13q33-q34 solute carrier family 15 (oligopeptide transporter), member 1 DOCK9 13q32.1 dedicator of cytokinesis 9 LOC390421 13 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) PHGDHL1 13 phosphoglycerate dehydrogenase like 1 GPR18 13q32 G protein-coupled receptor 18 EBI2 13q32.3 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) LOC390422 13 similar to Epstein-Barr virus induced gene 2 TM9SF2 13q32.2 transmembrane 9 superfamily member 2 CLYBL 13q32.3 citrate lyase beta like ZIC5 13q32.2 Zic family member 5 (odd-paired homolog, Drosophila) ZIC2 13q32 Zic family member 2 (odd-paired homolog, Drosophila) PCCA 13q32 propionyl Coenzyme A carboxylase, alpha polypeptide LOC87769 13q32.3 hypothetical protein BC004360 FLJ14624 13q32.3 hypothetical protein FLJ14624 LOC390423 13 similar to ADP-ribosylation factor 4 VGCNL1 13q32.3 voltage gated channel like 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    61 - 7544 - 2069 - 2008 18499258
    57 - 7661 - 2068 - 2008 18499258
    - - 3994 - 1254 - 2008 18499258
    - - 4111 - 1253 - 2008 18499258
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestine   lowly
     liver   lowly
    Nervousbrainlimbic systemhippocampus moderately Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text
  • placenta, highly
  • strongly expressed in the developing brain
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal CZH1 domain, conserved among CZH proteins, and the Pleckstrin homology domain are involved in membrane localization, CDC42 activation, and regulation of dendrite growth
  • a DHR-2 (CZH-2) domain
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus TRG protein
    intraspecies paralog to DOCK11 (52p100))
    Homologene
    FAMILY
  • superfamily of guanine nucleotide exchange factors for Rho GTPases
  • Dock180-related family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • CDC42 guanine nucleotide exchange factor, having potential guanyl-nucleotide release factor activity
  • implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution
  • specific guanine-nucleotide exchange factor (GEF) for CDC42
  • plays an important role in dendrite growth in hippocampal neurons through activation of CDC42
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component dimerizes via the CDC42-binding CZH2 domain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CDC42 via the CZH2 doamin
  • interacting with Rac2 and Cdc42 (specifically recognize Rac2 and Cdc42 through its switch 1 as well as 2-3 regions)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted dendrite growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS