basic FUNCTION
| regulates neuronal polarity through local phosphorylation of stathmin/Op18 |
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induces multiple axon formation when over expressed and |
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prevents axon formation when it is knocked down |
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functions as an intracellular substrate for ErbB2 to promote Schwann cell migration |
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role of DOCK7 in the interplay between Schwann cell migration and myelination |
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signaling through DOCK7 negatively regulates Schwann cell differentiation and the onset of myelination, demonstrating the unexpected role of DOCK7 in the interplay between Schwann cell migration and myelination |
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negative role of DOCK7 in Schwann cell differentiation |
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exerts its effects by antagonizing the microtubule growth-promoting function of the centrosome-associated protein TACC3 |
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functions as an essential and downstream regulator of AGER-mediated cellular migration through the formation of dendritic pseudopodia |
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its action may involve the coordinated integration of CDC42/RAC1 signaling in the context of the membrane recruitment of a DOCK7 GEF complex |
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RAC1 guanine nucleotide exchange factor implicated in the genesis and polarization of newborn pyramidal neurons and in the morphological differentiation of GABAergic interneurons in the developing cortex |
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regulator of neuronal development |
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important regulator of microtubule assembly both in the context of neurogenesis and in the establishment of neuronal polarity |