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FLASH GENE
Symbol DOCK5 contributors: mct - updated : 11-01-2017
HGNC name dedicator of cytokinesis 5
HGNC id 23476
Location 8p21.2      Physical location : 25.042.286 - 25.270.618
Synonym symbol(s) FLJ21034
DNA
TYPE functioning gene
STRUCTURE 230.99 kb     0 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
53 - 10223 - 1870 - 2009 19004829
4 - 797 - 83 - 2009 19004829
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
SH3 domain, a DHR2 domain
HOMOLOGY
interspecies homolog to murine BC016533
Homologene
FAMILY DOCK family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • potential guanine nucleotide exchange factor
  • DOCK1 and DOCK5 are critical regulators of the fusion step during primary myogenesis
  • potential role of DOCK5 in human obesity
  • DOCK1 and DOCK5 are not the important exchange factors regulating RAC1 activity during the establishment and maintenance of the glomerular barrier
  • atypical guanine nucleotide exchange factor (GEF) for RAC1, that is essential for mast cell degranulation
  • is a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation
  • DOCK5 acts with DOCK2 in neutrophils to regulate multiple cellular functions
  • DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation
  • expression of TNS3 and DOCK5 concomitantly increase during osteoclast differentiation
  • DOCK5 and TNS3 cooperate for osteoclast activity, to ensure the correct organization of podosomes
  • is a key regulator of epithelial invasion and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • unlike DOCK5, DOCK1 bound to phosphatidic acid (PA) through the C-terminal polybasic amino acid cluster and was localized to dorsal ruffles
  • functions as a key signaling adaptor that links FCER1A signals to microtubule dynamics during mast cell degranulation
  • suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of RHO and RAC1 GTPases
  • TNS3 regulate DOCK5, a guanine nucleotide exchange factor for the GTPase RAC1, and to modulate podosome-based adhesion structures in osteoclasts
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    pharmacological inhibition of DOCK5 is a novel therapeutic route for fighting osteolytic diseases while preserving bone formation
    ANIMAL & CELL MODELS
  • adult Dock5(-/-) mice have increased trabecular bone mass, and also have normal hypertrophic cartilage and cartilage trabecular network
  • Dock5-deficient mice exhibit resistance to systemic and cutaneous anaphylaxis