Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DOCK4 contributors: npt/mct - updated : 21-03-2011
HGNC name dedicator of cytokinesis 4
HGNC id 19192
Location 7q31.1      Physical location : 111.366.164 - 111.846.462
Synonym symbol(s) KIAA0716, FLJ34238, MGC134911, MGC134912
DNA
TYPE functioning gene
STRUCTURE 480.30 kb     52 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D7S2420 - D7S692 - D7S525 - DOCK4 - D7S523 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
52 - 8343 - 1966 - 2006 16464467
- - - - - in the brain, eye and inner ear tissues (within the hair bundles along the stereocilia ) 2006 16464467
  • also called DOCK4-Ex49
  • binds to nucleotide free Rac as effectively as DOCK2 and DOCK4 and it is a potent Rac activator
  • - splicing - - - - 2008 18459162
  • splicing variant, whose exon1 and exon52 are different from the known one
  • bind to PIP(3)
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Nervousnerve   highly
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    Nervousepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SH3 domain
  • DHR-1 (CZH-1) domain
  • DHR-2 (CZH-2) domain, probably mediating the GEF activity
  • C terminal proline-rich region
  • HOMOLOGY
    interspecies ortholog to murine Dock4
    intraspecies homolog to KIAA0299
    Homologene
    FAMILY
  • DOCK 180 family proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role in the regulation of small GT Pases implicated in cellular motility, cell adhesion, and invasion
  • promotes cell migration by activating Rac1
  • may plays an important role in the regulation of cell migration through activation of Rac1, and RhoG is a key upstream regulator for DOCK4
  • may be regulated by PIP(3) to exert its function
  • involved in regulation of adherens junction between cells
  • mediates Wnt-induced Rac activation in the canonical Wnt/beta-catenin pathway
  • acts as a scaffold protein in the Wnt/beta-catenin pathway
  • potential function in dendritic morphogenesis in hippocampal neurons
  • Rac1 guanine exchange factor, regulating with dynamin cell migration by PDGF receptor endocytosis
  • CELLULAR PROCESS cell life
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    possible Rac-DOCK4-ABP harmonin-activated signaling pathway in regulating actin cytoskeleton organization in stereocilia
    a component
  • formed a complex with ELMO, and expression of active RhoG induced translocation of the DOCK4-ELMO complex from the cytoplasm to the plasma membrane and enhanced the DOCK4- and ELMO-dependent Rac1 activation and cell migration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the SH3 domain of CRK
  • interacts with nucleotide-free RAP1
  • binds to harmonin (USH1C)
  • cell & other
    REGULATION
    Other phosphorylated by GSK3beta, which enhances Wnt-induced Rac activation
    regulated by the small GTPase RhoG and its effector ELMO
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in prostate and ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS