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FLASH GENE
Symbol DOCK11 contributors: mct - updated : 09-03-2011
HGNC name dedicator of cytokinesis 11
HGNC id 23483
Location Xq24      Physical location : 117.629.871 - 117.820.123
Synonym name Zizimin2
Synonym symbol(s) FLJ32122, Zizimin2, FLJ43653, ZIZ2, bB128O4.1, ACG
DNA
TYPE functioning gene
STRUCTURE 190.00 kb     53 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
53 - 6638 - 2073 - 2008 18499258
EXPRESSION
Rna function DOCK10 and DOCK11 mRNAs were mainly expressed in peripheral blood (PB) leukocytes
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology domain
  • CZH2 domain
  • DHR2 domain
  • HOMOLOGY
    intraspecies homolog to DOCK9 (52p100)
    Homologene
    FAMILY
  • superfamily of guanine nucleotide exchange factors for Rho GTPases
  • CZH proteins family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution
  • activating CDC42
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein bound and activated CDC42 but not the CDC42-related proteins TC10 or TCL
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS