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FLASH GENE
Symbol DOCK10 contributors: mct - updated : 16-05-2022
HGNC name dedicator of cytokinesis 10
HGNC id 23479
Location 2q36.2      Physical location : 225.629.806 - 225.907.330
Synonym name
  • cDNA sequence,expressed in brain, 62kDa
  • protein zizimin 3
  • dopamine receptor interacting protein 2
    • Synonym symbol(s) KIAA0694, ZIZ3, FLJ20220, DRIP2, Nbla10300, DKFZp781A1532
    DNA
    TYPE functioning gene
    STRUCTURE 277.38 kb     56 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text cell-specific mechanisms regulate expression of the alternative first exon variants of DOCK10 in vertebrates (PMID: 21514340)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    56 - 7290 - 2199 - 2020 32112301
    56 - 7286 249.5 2186 - 2020 32112301
  • DOCK10.1
  • induced by IL4 in CLL cells, which demonstrates that the mechanism by which IL4 regulates DOCK10 is not isoform-specific
    • 56 - 7272 - 2180 - 2020 32112301
  • DOCK10.2
  • induction by interleukin-4 (IL4) in normal B lymphocytes and chronic lymphocytic leukemia (CLL) cells
    		•
    EXPRESSION
    Rna function DOCK10 and DOCK11 mRNAs were mainly expressed in peripheral blood (PB) leukocytes
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousbrain   lowly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunelymphoblast Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one pleckstrin homology domain
  • one DHR1 domain
  • one DHR2 domain
    • HOMOLOGY
    interspecies homolog to murine Dock10
    intraspecies homolog to DOCK9, DOCK11
    Homologene
    FAMILY
  • DOCK family, DOCK-D subgroup, superfamily of guanine nucleotide exchange factors for Rho GTPases
  • dedicator of cytokinesis (DOCK) family of Rho GTPase activators
  • CZH proteins family, Zizimin subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • guanine nucleotide exchange factor (GEF) activity may be mediated by the DHR2 domain
  • activates some small GTPases by exchanging GDP with GTP
  • interleukin-4 (IL4)-inducible gene in chronic lymphocytic leukemias
  • activating CDC42
  • Cdc42 GEF, and a key player in amoeboid migration
  • implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution
  • role for DOCK10 in IL4-induced B-cell activation
  • could represent a point of convergence for IL4 signalling and small Rho GTPase function in B cells
  • regulator of dendritic spine morphogenesis via a CDC42-mediated pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • DOCK10 negatively regulates membrane FCER2 expression, and negative regulation of FCER2 expression by DOCK10 could play a role in B cell maturation and function
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    silencing DOCK10 expression promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased RAC1 activation
    tumoral     --over  
    in poorly differentiated papillary thyroid carcinomas
    constitutional   deletion    
    in B cells was associated with a mild phenotype with normal B cell development and normal B cell spreading, polarization, motility, chemotaxis, aggregation, and Ig class switching
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS