SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| synaptic vesicles in neurons |
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translocation of DOC2B from a vesicular localization to the plasma membrane dependent upon the DOC2B/UNC13B interacting domain that binds specifically to UNC13B, whereas the association of DOC2B with intracellular membranes is dependent on its C2 domains |
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associated with insulin vesicles and translocated to plasma membrane within several minutes upon high-glucose stimulation followed by an interaction with syntaxin4, but not syntaxin1 |
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synaptic protein that translocates to the plasma membrane (PM) after small elevations in intracellular calcium concentration |
basic FUNCTION
| having a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse |
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with UNC13B are implicated in Ca2+-dependent neurotransmitter release |
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plays a role in dynein-dependent intracellular vesicle transport |
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acts as a priming factor and increases the number of fusion-competent vesicles |
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calcium-dependent priming factor and its activity at the plasma membrane enables efficient expansion of the fusion pore, leading to increased catecholamine release |
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SNARE related protein, translocated from intracellular compartment to the plasma membrane upon glucose stimulation, and binding syntaxin4, but not syntaxin1, in pancreatic beta-cells |
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may be a positive regulator of membrane fusion and have a ole on second-phase secretion of insulin |
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SNARE regulator for the second-phase secretion of insulin |
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acting as Ca2+ sensor to trigger spontaneous neurotransmitter release |
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DOC2A, DOC2B are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism |
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slow Ca2+ sensor that plays a critical role in asynchronous neurotransmitter release |
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regulates Ca2+-dependent spontaneous synaptic vesicle (SV) fusion events |
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DOC2A, DOC2B functions as Ca2+ sensors for slow asynchronous SV exocytosis in hippocampal neurons |
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its actions in glucose homeostasis may be related to its ability to bind STXBP3 and/or directly promote fusion of insulin granules and SLC2A1 vesicles in a stimulus-dependent manner |