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FLASH GENE
Symbol DOC2B contributors: mct/pgu - updated : 16-02-2013
HGNC name double C2-like domains, beta
HGNC id 2986
Location 17p13.3      Physical location : 6.010 - 31.420
Synonym name double C2-like domains, beta-like
Synonym symbol(s) Doc2-beta
DNA
TYPE functioning gene
STRUCTURE 25.41 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388439 17 LOC388439 LOC390818 17 similar to RPL23AP7 protein SH3GLP3 17q24 SH3-domain GRB2-like pseudogene 3 LOC388443 17 LOC388443 DOC2B 17p13.3 double C2-like domains, beta LOC390820 17 similar to hypothetical protein LOC130888 LOC388435 17 LOC388435 LOC388453 17 LOC388453 LOC388440 17 similar to cytokine LOC388436 17 hypothetical gene supported by BC058012 LOC388444 17 similar to LOC147111 protein LOC388445 17 similar to hypothetical protein BC009233 LOC388446 17 similar to myeloid-associated differentiation marker GCGR 17q25 glucagon receptor LOC388438 17 similar to MEGF11 protein LOC348262 17 hypothetical protein LOC348262 LOC388441 17 similar to aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100 LOC388437 17 similar to hypothetical protein DKFZp434F142 LOC388447 17 similar to dysferlin-interacting protein 1 LOC390752 17 similar to Buccalin precursor LOC388448 17 similar to prolyl 4-hydroxylase, beta subunit; v-erb-a avian erythroblastic leukemia viral oncogene homolog 2-like; disulfide isomerase; protein disulfide isomerase/oxidoreductase; thyroid hormone-binding protein p55; glutathione-in RPH3AL 17p13.3 rabphilin 3A-like (without C2 domains) KPNA2 17q23.1-q23.3 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) LOC390819 17 similar to aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100 LOC388442 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388449 17 LOC388449 LOC388450 17 similar to Ethanolamine-phosphate cytidylyltransferase (Phosphorylethanolamine transferase) (CTP:phosphoethanolamine cytidylyltransferase) LOC388451 17 hypothetical gene supported by AL137626; NM_016538 LOC388452 17 hypothetical gene supported by BC012327; NM_002359
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2023 46 412 - 1997 9195900
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye lens, eye anterior segment, optic nerve, retina, RPE, choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal fragment containing the DYNLT1-interacting domain induces changes in the intracellular localization of cation-independent mannose 6-phosphate receptor and its ligand, cathepsin D, which are transported from trans-Golgi network to late endosomes
  • C-terminal fragment containing two C2-like domains that interact with Ca2+ and phospholipid
  • mono polymer homomer , dimer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • synaptotagmin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • synaptic vesicles in neurons
  • translocation of DOC2B from a vesicular localization to the plasma membrane dependent upon the DOC2B/UNC13B interacting domain that binds specifically to UNC13B, whereas the association of DOC2B with intracellular membranes is dependent on its C2 domains
  • associated with insulin vesicles and translocated to plasma membrane within several minutes upon high-glucose stimulation followed by an interaction with syntaxin4, but not syntaxin1
  • synaptic protein that translocates to the plasma membrane (PM) after small elevations in intracellular calcium concentration
  • basic FUNCTION
  • having a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse
  • with UNC13B are implicated in Ca2+-dependent neurotransmitter release
  • plays a role in dynein-dependent intracellular vesicle transport
  • acts as a priming factor and increases the number of fusion-competent vesicles
  • calcium-dependent priming factor and its activity at the plasma membrane enables efficient expansion of the fusion pore, leading to increased catecholamine release
  • SNARE related protein, translocated from intracellular compartment to the plasma membrane upon glucose stimulation, and binding syntaxin4, but not syntaxin1, in pancreatic beta-cells
  • may be a positive regulator of membrane fusion and have a ole on second-phase secretion of insulin
  • SNARE regulator for the second-phase secretion of insulin
  • acting as Ca2+ sensor to trigger spontaneous neurotransmitter release
  • DOC2A, DOC2B are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism
  • slow Ca2+ sensor that plays a critical role in asynchronous neurotransmitter release
  • regulates Ca2+-dependent spontaneous synaptic vesicle (SV) fusion events
  • DOC2A, DOC2B functions as Ca2+ sensors for slow asynchronous SV exocytosis in hippocampal neurons
  • its actions in glucose homeostasis may be related to its ability to bind STXBP3 and/or directly promote fusion of insulin granules and SLC2A1 vesicles in a stimulus-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DOC2B-UNC13B interactions are stimulated by phorbol ester through the C1 domain of UNC13B
  • interacting with DYNLT1
  • binding to SNARE complexes in competition with synaptotagmin-1
  • DOC2B as well as DOC2A bound to liposomes harboring phosphatidylserine (PS) in response to Ca2+
  • TCTEX1D2 associate with syntaxin 4 in an insulin-dependent manner and inhibit DOC2B binding to syntaxin 4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS