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FLASH GENE
Symbol DOC2B contributors: mct/pgu - updated : 16-02-2013
HGNC name double C2-like domains, beta
HGNC id 2986
Location 17p13.3      Physical location : 6.010 - 31.420
Synonym name double C2-like domains, beta-like
Synonym symbol(s) Doc2-beta
DNA
TYPE functioning gene
STRUCTURE 25.41 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2023 46 412 - 1997 9195900
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye lens, eye anterior segment, optic nerve, retina, RPE, choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal fragment containing the DYNLT1-interacting domain induces changes in the intracellular localization of cation-independent mannose 6-phosphate receptor and its ligand, cathepsin D, which are transported from trans-Golgi network to late endosomes
  • C-terminal fragment containing two C2-like domains that interact with Ca2+ and phospholipid
  • mono polymer homomer , dimer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • synaptotagmin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • synaptic vesicles in neurons
  • translocation of DOC2B from a vesicular localization to the plasma membrane dependent upon the DOC2B/UNC13B interacting domain that binds specifically to UNC13B, whereas the association of DOC2B with intracellular membranes is dependent on its C2 domains
  • associated with insulin vesicles and translocated to plasma membrane within several minutes upon high-glucose stimulation followed by an interaction with syntaxin4, but not syntaxin1
  • synaptic protein that translocates to the plasma membrane (PM) after small elevations in intracellular calcium concentration
  • basic FUNCTION
  • having a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse
  • with UNC13B are implicated in Ca2+-dependent neurotransmitter release
  • plays a role in dynein-dependent intracellular vesicle transport
  • acts as a priming factor and increases the number of fusion-competent vesicles
  • calcium-dependent priming factor and its activity at the plasma membrane enables efficient expansion of the fusion pore, leading to increased catecholamine release
  • SNARE related protein, translocated from intracellular compartment to the plasma membrane upon glucose stimulation, and binding syntaxin4, but not syntaxin1, in pancreatic beta-cells
  • may be a positive regulator of membrane fusion and have a ole on second-phase secretion of insulin
  • SNARE regulator for the second-phase secretion of insulin
  • acting as Ca2+ sensor to trigger spontaneous neurotransmitter release
  • DOC2A, DOC2B are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism
  • slow Ca2+ sensor that plays a critical role in asynchronous neurotransmitter release
  • regulates Ca2+-dependent spontaneous synaptic vesicle (SV) fusion events
  • DOC2A, DOC2B functions as Ca2+ sensors for slow asynchronous SV exocytosis in hippocampal neurons
  • its actions in glucose homeostasis may be related to its ability to bind STXBP3 and/or directly promote fusion of insulin granules and SLC2A1 vesicles in a stimulus-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DOC2B-UNC13B interactions are stimulated by phorbol ester through the C1 domain of UNC13B
  • interacting with DYNLT1
  • binding to SNARE complexes in competition with synaptotagmin-1
  • DOC2B as well as DOC2A bound to liposomes harboring phosphatidylserine (PS) in response to Ca2+
  • TCTEX1D2 associate with syntaxin 4 in an insulin-dependent manner and inhibit DOC2B binding to syntaxin 4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS