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FLASH GENE
Symbol DOC2A contributors: mct/npt/pgu - updated : 16-02-2013
HGNC name double C2-like domains, alpha
HGNC id 2985
Location 16p11.2      Physical location : 30.016.836 - 30.022.401
Synonym symbol(s) Doc2, Doc2-alpha
DNA
TYPE functioning gene
STRUCTURE 5.57 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388243 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase SPN 16p11.2 sialophorin (gpL115, leukosialin, CD43) QPRT 16q13 quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) FLJ35681 16p12.1 hypothetical protein FLJ35681 ZG16 16p12.1 zymogen granule protein 16 KIF22 16p11.2 kinesin family member 22 MAZ 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) LOC112476 16p12.1 similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31 MGC4606 16p12.1 hypothetical protein MGC4606 MVP 16p11.2 major vault protein CDIPT 16p12.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) PSK-1 16p12.1 type I transmembrane receptor (seizure-related protein) KCTD13 16p11.2 potassium channel tetramerisation domain containing 13 LOC253982 16p12.1 hypothetical protein LOC253982 LOC124446 16p12.1 hypothetical protein BC017488 PSK 16p12.1 hypothetical protein BC017488 TAO1 16p11.2 hypothetical protein BC017488 HIRIP3 16q13 HIRA interacting protein 3 FLJ90652 16p12.1 hypothetical protein FLJ90652 DOC2A 16q13 double C2-like domains, alpha DKFZP434I2117 16p12.1 hypothetical protein DKFZp434I2117 ALDOA 16q22.2 aldolase A, fructose-bisphosphate PPP4C 16p12-p11 protein phosphatase 4 (formerly X), catalytic subunit TBX6 16p11.2 T-box 6 MGC10500 16p12.1 hypothetical protein MGC10500 MGC4171 16p12.1 hypothetical protein MGC4171 MAPK3 16p11.2 mitogen-activated protein kinase 3 CORO1A 16p11.2-q11.2 coronin, actin binding protein, 1A LOC339088 16p12.1 similar to My016 protein SULT1A3 16p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 LOC387619 16 PI-3-kinase-related kinase SMG-1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2089 44 400 - 1995 7826360
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
 brainforebraincerebral cortexfrontal 
 brain   specific Homo sapiensAdult
 nervespinal nervesciatic  
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal Mid domain (amino acid residues 13-37) and containing the UNC13A-interacting domain
  • C2A domain
  • C terminus containing the Ca(2+)-binding C2B domain, with a polybasic sequence functioning as a binding site for syntaxin-1a/SNAP-25 heterodimer and controling the number of 'readily releasable' vesicles in neuroendocrine cells
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • with UNC13B highly concentrated on synaptic vesicles and the presynaptic plasma membrane
  • colocalized with UNC13D on secretory lysosomes
  • basic FUNCTION
  • may be having a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse
  • exhibits Ca(2+)-dependent phospholipid-binding activity through its C2A domain, and the Ca(2+)-binding activity is thought to be important for the regulation of Ca(2+)-dependent exocytosis
  • DOC2A, DOC2B are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism
  • specifically modulates the asynchronous phase of neurotransmitter release
  • emerges as a candidate Ca2+ sensor that might function to trigger asynchronous exocytosis in neurons
  • slow Ca2+ sensor that plays a critical role in asynchronous neurotransmitter release
  • regulates Ca2+-dependent spontaneous synaptic vesicle (SV) fusion events
  • DOC2A, DOC2B functions as Ca2+ sensors for slow asynchronous SV exocytosis in hippocampal neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DOC2A-UNC13D system regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with UNC13B through the N-terminal region (the Mid domain, amino acid residues 13-37), interaction required for Ca2+-dependent neurotransmitter release from intact neuron
  • DOC2B as well as DOC2A bound to liposomes harboring phosphatidylserine (PS) in response to Ca2+
  • interacts with UNC13A, a member of the Munc13 family, through its N-terminalUNC13A-interacting domain and the DOC2A-UNC13A system is implicated in Ca(2+)-dependent synaptic vesicle exocytosis
  • interacting with UNC13D through its two regions, the N terminus containing the UNC13A-interacting domain and the C terminus containing the Ca(2+)-binding C2B domain
  • bind to phospholipids in response to Ca2+
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS