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FLASH GENE
Symbol DNPEP contributors: npt - updated : 05-04-2006
HGNC name aspartyl aminopeptidase
HGNC id 2981
Location 2q35      Physical location : 220.238.179 - 220.252.662
Synonym symbol(s) DAP, ASPEP
EC.number 3.4.11.21
DNA
TYPE functioning gene
STRUCTURE 14.48 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2438 53.3 485 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven histidine residues, important in catalysis and enzyme integrity
  • three conserved glutamates
  • five conserved aspartes
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Dmpep
    homolog to yeast aminopeptidase L
    Homologene
    FAMILY
  • peptidase M18 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • removing glutamyl or aspartyl residues from N terminal acidic amino acid containing peptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    peptide metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS