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FLASH GENE

Symbol

DNPEP

contributors: npt - updated : 05-04-2006

HGNC name	aspartyl aminopeptidase
HGNC id	2981

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q35      Physical location : 220.238.179 - 220.252.662
Synonym symbol(s)	DAP, ASPEP
EC.number	3.4.11.21

DNA

TYPE	functioning gene
STRUCTURE	14.48 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DNPEP 15 - 2438 53.3 485 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven histidine residues, important in catalysis and enzyme integrity
	three conserved glutamates
	five conserved aspartes

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	homolog to murine Dmpep
	homolog to yeast aminopeptidase L

Homologene

FAMILY

peptidase M18 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

removing glutamyl or aspartyl residues from N terminal acidic amino acid containing peptides

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

peptide metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS