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FLASH GENE
Symbol DNER contributors: mct/pgu - updated : 06-11-2012
HGNC name delta/notch-like EGF repeat containing
HGNC id 24456
Location 2q36.3      Physical location : 230.222.345 - 230.579.286
Synonym name
  • delta-notch-like EGF repeat-containing transmembrane protein
  • hypothetical protein DNER
  • Synonym symbol(s) UNQ26, bet, QPRR262, H_NH0150O02.1
    DNA
    TYPE functioning gene
    STRUCTURE 356.94 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389077 2 LOC389077 GL004 2q37.1 LOC389077 FLJ22800 2q36.3 hypothetical protein FLJ22800 HRB 2q36 HIV-1 Rev binding protein DKFZp547H025 2q36.3 hypothetical protein DKFZp547H025 LOC389078 2 hypothetical gene supported by AK125767 SLC19A3 2q37 solute carrier family 19, member 3 CCL20 2q35-q36 chemokine (C-C motif) ligand 20 FLJ25955 2q36.3 hypothetical protein FLJ25955 SKIP 17p13 hypothetical protein FLJ25955 FLJ20701 2q37.1 hypothetical protein FLJ20701 DNER 2q37.1 delta-notch-like EGF repeat-containing transmembrane TRIP12 2q36.1 thyroid hormone receptor interactor 12 LOC130888 FLJ30794 SP110 2q37.1 SP110 nuclear body protein SP140 2q36.1 SP140 nuclear body protein LOC93349 2q37.1 hypothetical protein BC004921 SP100 2q37.1 nuclear antigen SP100 HMG1L3 2q35 high-mobility group (nonhistone chromosomal) protein 1-like 3 LOC389079 2 similar to tropomyosin 3 LOC391489 2 similar to LOC93349 protein MO25 2q37.1 MO25 protein ITM2C 2q37 integral membrane protein 2C GPR55 2q37 G protein-coupled receptor 55 TSARG1 LOC389080 2 LOC389080 PSMD1 2q37.1-q37.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 HTR2B 2q36.3-q37.1 5-hydroxytryptamine (serotonin) receptor 2B FLJ12584 2q37.1 hypothetical protein FLJ12584 FLJ23510 2q37.1 hypothetical protein FLJ23510 LOC389081 2 LOC389081 B3GNT7 2q36.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 LOC389082 2 similar to archease NCL 2q12-qter nucleolin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3272 - 737 - 2005 15965470
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Hearing/Equilibriumearinnercochlea  
    Nervousbrainhindbraincerebellum predominantly Homo sapiens
    Reproductivefemale systemuteruscervix  
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensorystato-auditory  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumepithelial cell
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    Nervouspyramidal cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text expressed in hair cells and vestibular ganglion neurons during development and in adults
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single transmembrane region
  • ten distincts EGF-like motifs, extracellular EGF-like repeats
  • potential tyrosine-based sorting signal
  • a typical tyrosine-type sorting signal
  • a dileucine-type sorting signal
  • HOMOLOGY
    interspecies homolog to murine Dner
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text PTPRZ1 and DNER displayed patchy colocalization in the dendrites of Purkinje cells
    basic FUNCTION
  • playing crucial roles in establishing the neuronal networks in the olfactory system, cerebellum, and hippocampus
  • mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling
  • mediates Notch signaling by cell-cell interaction
  • contributes to the morphological and functional maturation of Bergmann glia via the Notch signaling pathway, and is essential for precise cerebellar development
  • potential role for DNER and PTPRZ1 in hair-cell development and possibly in the specification of tonotopy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
  • may be binding to clathrin coat-associated protein complex AP1
  • neuron-specific transmembrane protein, ligand of NOTCH during cellular morphogenesis of Bergmann glia
  • transmembrane Notch ligand
  • cell & other
    REGULATION
    Other surface expression of DNER is regulated by clathrin-dependent and -independent endocytosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS