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FLASH GENE
Symbol DND1 contributors: mct - updated : 11-07-2011
HGNC name dead end homolog 1 (zebrafish)
HGNC id 23799
Location 5q31.3      Physical location : 140.050.381 - 140.053.171
Synonym name
  • dead end protein
    • Synonym symbol(s) RBMS4, MGC34750
    DNA
    TYPE functioning gene
    STRUCTURE 2.79 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1681 - 353 - 2003 12932328
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrinethyroid    
    Reproductivefemale systemplacenta   
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two RRM (RNA recognition motif) domains
  • a single-strand RNA-binding domain in the N-terminus
    • HOMOLOGY
    interspecies ortholog to rattus Dnd1_predicted
    ortholog to murine Dnd1
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may play a role during primordial germ cell (PGC) development
  • role of DND1 in protecting certain mRNAs from miRNA-mediated repression
  • essential for maintaining the viability of germ cells
  • able to bind to the 3prime-untranslated region (UTR) of messenger RNAs (mRNAs) to displace micro-RNA (miRNA) interaction with mRNA
  • possible role of DND1-APOBEC3 interaction in modulating miRNA-mediated mRNA repression
  • can potentially regulates mitotic arrest in male germ cells through translational regulation of cell cycle genes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacts specifically with APOBEC3(APOBEC3 interacts with cellular RNA-binding proteins and to mRNA to inhibit miRNA-mediated repression of mRNA, and interaction of DND1 and APOBEC3 could be one mechanism for maintaining viability of germ cells and for preventing germ cell tumor development)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to testicular germ cell tumors (rare variant)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1(Ter/Ter)) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of the gonad in both sexes