basic FUNCTION
| hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis |
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potentially involved in naturally occurring apoptosis in developing nervous systems |
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plays an active role in lymphoma cell sensitization to VP-16 and its deficiency may constitute a novel mechanism of drug resistance in these cells |
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DNASE1L3 is uniquely capable of digesting chromatin in microparticles released from apoptotic cells |
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is an endonuclease to degrade the chromatin of apoptotic or necrotic cells |
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plays a role in circulating plasma DNA homeostasis by enhancing fragmentation and influencing end-motif frequencies |
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distinct role of DNASE1L3 as a regulator of the physical form and availability of cell-free DNA and may have important implications for the mechanism whereby this enzyme prevents autoimmunity |
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DNASE1L3 was the endonuclease responsible for generating cell-free DNA in acetaminophen-induced hepatocyte necrosis |
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DNASE1L3 digestion within the plasma might be a subsequent step that would result in the typical homeostatic cell-free DNA |
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DNASE1L3 plays a role in the fragmentation of plasma DNA |
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is an important player in the fragmentation of plasma DNA, which appears to act in a cell-extrinsic manner to regulate plasma DNA size and motif frequency |
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DNASE1L3 has a strong preference for cutting DNA sequences adjacent to the CC dinucleotides regardless of the presence of nucleosomal structural proteins |
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is an important component of the mechanism for maintaining plasma DNA homeostasis |