Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DNAL1 contributors: mct - updated : 25-08-2011
HGNC name axonemal dynein light chain 1
HGNC id 23247
Corresponding disease
ICS15 immotile cilia syndrome 15
Location 14q24.3      Physical location : 74.111.577 - 74.168.647
Synonym name chromosome 14 open reading frame 168
Synonym symbol(s) MGC12435, C14orf168, 1700010H15RiK
DNA
TYPE functioning gene
STRUCTURE 58.85 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 8584 - 151 - 2005 15845866
8 - 8538 - 190 - 2005 15845866
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunethymus   highly
Nervousbraindiencephalonamygdala moderately
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
eight leucine rich repeat motifs
HOMOLOGY
interspecies ortholog to murine Dnalc1 (89 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • dynein light chain 1, potential regulator of the mitotic function of protein phosphatase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of DNAL1 with the dynein heavy chain (DNAH) and tubulin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS15
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS