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FLASH GENE
Symbol DNAJC7 contributors: mct - updated : 22-08-2014
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 7
HGNC id 12392
Location 17q11.2      Physical location : 40.128.438 - 40.169.715
Synonym name
  • tetratricopeptide repeat domain 2
  • TPR repeat protein 2
  • cytosoplasmic CAR retention protein
  • Synonym symbol(s) TPR2, TTC2, DANJC7, DJ11, DJC7, CCRP
    DNA
    TYPE functioning gene
    STRUCTURE 44.95 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2096 - 494 - 2003 14573755
    14 - 1864 - 438 - 2003 14573755
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainmidbrain  predominantly
     brain   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine tetratricopeptide repeats
  • a region of similarity with the DnaJ protein family
  • and a coiled coil domain within the TPR domain
  • two N-terminal tetratricopeptide repeat domains
  • a C-terminal DNAJ domain
  • HOMOLOGY
    interspecies homolog to murine Dnajc7
    homolog to Drosophila Tpr2
    intraspecies homolog to PRKP1
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • implicated in steroid receptor chaperoning
  • participates in TP53/MDM2 negative feedback regulatory pathway, and thereby enhancing the stability and activity of TP53
  • has an ability to enhance TP53-dependent transcriptional activation
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS development
    text preventing protein aggregation
    PATHWAY
    metabolism
    signaling
    a component
  • DNAJC7 directly interacts with the ligand-binding domain of NR1I3 and mediates the formation of a cytoplasmic NR1I3-DNAJC7-HSP90 ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GAP-related domain of NF1,via its TPR region
  • DNAJC7 is associated with TP53 in mammalian cells
  • ubiquitin-proteasomal regulation of DNAJC7 and HSPA4 are important contributors to the regulation of cytoplasmic NR1I3 levels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS