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FLASH GENE
Symbol DNAJC6 contributors: mct/npt - updated : 08-11-2017
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 6
HGNC id 15469
Corresponding disease
PARK19 Parkinson disease 19
Location 1p31.3      Physical location : 65.730.429 - 65.881.552
Genatlas name auxilin
Synonym name
  • homolog to bovin auxilin, >100kDa
  • putative tyrosine-protein phosphatase auxilin
  • DnaJ (Hsp40) homolog, subfamily B, member 6
  • Synonym symbol(s) KIAA0473, MGC129914, MGC129915, MGC48436, DJC6, PARK19
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 151.18 kb     19 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ10884 1p32.1 hypothetical protein FLJ10884 LOC388637 1 similar to LOC163782 protein USP1 1p32.1-p31.3 ubiquitin specific protease 1 ANGPTL3 1p31 angiopoietin-like 3 AUTL1 1p31.3 AUT-like 1, cysteine endopeptidase (S. cerevisiae) LOC199897 1p32.1 hypothetical LOC199897 LOC388638 1 LOC388638 FOXD3 1p32-p31 forkhead box D3 ALG6 1p31.3 forkhead box D3 ITGB3BP 1p31.3 integrin beta 3 binding protein (beta3-endonexin) KIAA1799 1p31.3 KIAA1799 protein PGM1 1p22.3 phosphoglucomutase 1 ROR1 1p32-p31 receptor tyrosine kinase-like orphan receptor 1 MGC35130 1p31.3 hypothetical protein MGC35130 KIAA1573 1p31.3 KIAA1573 protein KIAA1579 1p31.3 hypothetical protein FLJ10770 JAK1 1p31.3 Janus kinase 1 (a protein tyrosine kinase) LOC391045 1 similar to Solute carrier family 2, facilitated glucose transporter, member 3 (Glucose transporter type 3, brain) MRPS21P1 1p31.3 mitochondrial ribosomal protein S21 pseudogene AK3 1p31 adenylate kinase 3 DNAJC6 1pter-q31.3 DnaJ (Hsp40) homolog, subfamily C, member 6 LEPR 1p31 leptin receptor PDE4B 1p31 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) DKFZp761D221 1p31.3 hypothetical protein DKFZp761D221 FLJ40873 1p31.3 hypothetical protein FLJ40873 INSL5 1p31.1-p22.3 insulin-like 5 FLJ23129 1p31.3 hypothetical protein FLJ23129 MI-ER1 1p31.3 mesoderm induction early response 1 SLC35D1 1p32-p31 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 IL23R 1p31.3-p31.2 interleukin-23 receptor IL12RB2 1p31.3-p31.2 interleukin 12 receptor, beta 2 PAI-RBP1 1p31-p22 PAI-1 mRNA-binding protein LOC391046 1 similar to heterogeneous nuclear ribonucleoprotein C isoform b; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein GADD45A 1p31.2-p31.1 growth arrest and DNA-damage-inducible, alpha GNG12 1p33-p31 guanine nucleotide binding protein (G protein), gamma 12 LOC391047 1 similar to NAD-dependent deacetylase sirtuin 5 (SIR2-like protein 5) ARHI 1p31 ras homolog gene family, member I FLJ23091 1p31.2 putative NFkB activating protein 373 LOC149224 1p31.2 similar to 40S ribosomal protein S7 (S8) RPE65 1p31 retinal pigment epithelium-specific protein 65kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5750 - 913 - 2014 25446072
    20 - 5916 - 900 - 2014 25446072
    19 - 5968 - 970 - 2014 25446072
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Nervousbrain   highly
     nerve   highly
     spinal cord   predominantly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal conserved J domain through which they form a complex with heat shock cognate 70 (HPA8), enhancing the chaperone ATPase activity
  • a C2 tensin-type domain
  • one phosphatase tensin-type domain
  • a conserved 70-amino acid J domain, usually at the N terminus
  • a glycine/phenylalanine (G/F)-rich region
  • a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain
  • HOMOLOGY
    interspecies homolog to bovin auxilin
    ortholog to murine Dnajc6
    homolog to C.elegans dnj-25
    Homologene
    FAMILY
  • DNAJ/HSP40 family of proteins
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having a protein phosphatase activity
  • involved in protein amino acid dephosphorylation
  • regulate molecular chaperone activity by stimulating ATPase activity
  • having multiple protein-protein interactions and involved in endocytic trafficking
  • required in Notch signaling cells for ligand internalization and signaling (Eun 2008)
  • crucial role of Auxilin in signaling, at least in part, through the generation of free Clathrin (Eun 2008)
  • facilitate the uncoating of clathrin-coated vesicles but also prevent the formation of nonproductive clathrin cages in the cytosol (Hirst 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • cofactor for Hsc70-mediated uncoating of clathrin-coated vesicles (CCVs) (Hirst 2008)
  • protein
  • interacts with HSPA8/HSC70
  • interacts with clathrin heavy chains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PARK19
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in HCC (hepatocellular carcinoma) tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a marker of poor outcome in hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS