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FLASH GENE

Symbol

DNAJC2

contributors: mct - updated : 26-09-2012

HGNC name	DnaJ (Hsp40) homolog, subfamily C, member 2
HGNC id	13192

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q22.1      Physical location : 102.952.921 - 102.985.320
Synonym name	M-phase phosphoprotein 11
	zuotin related factor 1
Synonym symbol(s)	MPP11, MPHOSPH11, ZRF1, ZUO1, zuotin

DNA

TYPE	functioning gene
STRUCTURE	32.40 kb     17 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in a segment commonly deleted in myeloid malignancies

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001129887 15 - 2053 NP_001123359 - 568 - 2005 16002468 NM_014377 17 - 2212 NP_055192 - 621 - 2005 16002468

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       moderately endocrine brain diencephalon pituitary     Reproductive female system breast mammary gland   moderately   female system ovary     highly   male system prostate         male system testis     highly Respiratory lung         Skin/Tegument skin       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage
cell lines
fluid/secretion	blood

at STAGE

cell cycle

cell cycle, M

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal zuotin-homology domain fused to a C-terminal two-repeat MYB domain
	a J domain
	a evolutionarily conserved zuotin domain

conjugated

PhosphoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to Drosophila CG10565
	homolog to C.elegans dnj-11
	ortholog to yeast ribosome-associated J protein Zuo

Homologene

FAMILY

CATEGORY

chaperone/stress , regulatory , DNA associated , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus
text	localized to the cytosol and associates with ribosomes

basic FUNCTION	acting as a cell cycle regulator
	implicated in the regulation of cell growth
	specifically recruited to histone H2A when it is ubiquitinated at Lys&
	8201;119 by means of a novel ubiquitin-interacting domain that is located in the evolutionarily conserved zuotin domain
	at the onset of differentiation, specifically displaces polycomb-repressive complex 1 (PRC1) from chromatin and facilitates transcriptional activation
	specifically binds to monoubiquitinated histone H2A and derepresses Polycomb target genes at the onset of cellular differentiation
	recruited to typical Polycomb target genes, thereby putting it in a position to have an impact on differentiation and development

CELLULAR PROCESS	cell cycle
	nucleotide, transcription, regulation
	protein, post translation, folding

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms a stable complex with HSPA14 (chaperones DNAJC2 and HSPA14 form the ribosome-associated complex)

INTERACTION

DNA

binding

RNA

small molecule

protein	reactive with antibodies anti MPM2
	unfolded protein
	heat shock protein

cell & other

REGULATION

Other

phosphorylated in M phase

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   extensively overexpressed in leukemic cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   attractive target for leukemia T cell therapy

ANIMAL & CELL MODELS