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FLASH GENE
Symbol DNAJC19 contributors: mct - updated : 18-08-2010
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 19
HGNC id 30528
Corresponding disease
CMDA cardiomyopathy, dilated with ataxia syndrome
Location 3q26.33      Physical location : 180.701.499 - 180.707.562
Synonym name
  • homolog of yeast TIM14
  • translocase of the inner mitochondrial membrane 14
  • mitochondrial import inner membrane translocase subunit TIM14
    • Synonym symbol(s) TIM14, TIMM14
    DNA
    TYPE functioning gene
    STRUCTURE 6.07 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1476 - 116 - Mokranjac (2003)
    also called TIM14 variant 1
    5 - 1488 - 91 - Mokranjac (2003)
    also called TIM14 variant 2
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     salivary gland   highly
    Endocrineneuroendocrinepituitary  highly
    Reproductivemale systemprostate  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast inner mitochondrial cochaperones
    ortholog to yeast Pam18
    Homologene
    FAMILY
  • TIM14 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • constituent of the mitochondrial import motor required for the activation of mtHsp70
  • required for the translocation of transit
    • peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner
  • may act as a co-chaperone that stimulate the ATP-dependent activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44,
    • TIMM16/MAGMAS and TIMM14/DNAJC19
  • MAGMAS:DNAJC19 subcomplex is associated with TIMM23 complex and thus regulates mitochondrial import process (Sinha 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TIMM44 and mtHsp70 in an ATP-dependent manner
  • stable interaction between MAGMAS and DNAJC19 that plays a crucial role in tethering of DNAJC19 at the translocon and perhaps regulating human import motor activity (Sinha 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMDA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS