basic FUNCTION
| acting as a DnaJ-like partner of HSPA5, because a recombinant protein carrying the J-domain of DNAJC10 associated with HSPA5 in an ATP-dependent manner and enhanced its ATPase activity |
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can function as a strong disulfide reductase once it accepts electrons from electron donors |
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DNAJC10 and DNAJB9 play important roles in the ER-associated degradation (ERAD) of unfolded secretory proteins |
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contributes to ER protein quality control in the salivary gland |
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crucial role is to reduce non-native disulfides formed during productive folding and this requirement is dependent on its interaction with HSPA5 |
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acts as the ER reductase, both preparing misfolded proteins for degradation and catalyzing the folding of proteins that form obligatory non-native disulfides |