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FLASH GENE
Symbol DNAJC10 contributors: mct - updated : 23-12-2013
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 10
HGNC id 24637
Location 2q31.3      Physical location : 183.580.998 - 183.643.255
Synonym name
  • J-domain-containing protein disulfide isomerase-like protein
  • macrothioredoxin
  • ER-resident protein ERdj5
  • J-domain-containing protein disulfide isomerase-like protein
  • Synonym symbol(s) JPDI, ERdj5, MGC104194
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 63.98 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 5921 91 793 - 2003 14587667
    contain a DnaJ domain and four thioredoxin domains
    23 splicing 5783 - 747 - 2003 14587667
    contain a DnaJ domain and four thioredoxin domains
    - splicing 2982 - 275 - 2003 14587667
    only contains an N-terminus DnaJ domain and one thioredoxin active set
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivefemale systembreastmammary gland  
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a J-domain motif adjacent to the N-terminal translocation signal sequence
  • six tandem thioredoxin domains that can be divided into the N- and C-terminal clusters
  • three CXPC motifs, consistent with reports that the redox potential of CXPC motifs contained in thioredoxin superfamily proteins is reducing
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY protein disulfide isomerase family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • acting as a DnaJ-like partner of HSPA5, because a recombinant protein carrying the J-domain of DNAJC10 associated with HSPA5 in an ATP-dependent manner and enhanced its ATPase activity
  • can function as a strong disulfide reductase once it accepts electrons from electron donors
  • DNAJC10 and DNAJB9 play important roles in the ER-associated degradation (ERAD) of unfolded secretory proteins
  • contributes to ER protein quality control in the salivary gland
  • crucial role is to reduce non-native disulfides formed during productive folding and this requirement is dependent on its interaction with HSPA5
  • acts as the ER reductase, both preparing misfolded proteins for degradation and catalyzing the folding of proteins that form obligatory non-native disulfides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component part of supramolecular functional ERAD complex, comprising EDEM1, DNAJC10, and HSPA5
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    two zinc ions per monomer
    protein
  • interacts with HSPA5 via its J domain
  • binding to EDEM1
  • DNAJB9, DNAJC10 promote turnover of misfolded SFTPC and this activity is dependent on their ability to stimulate HSPA5 ATPase activity
  • interacts with EDEM1 and reduces EDEM1-recruited substrates, leading to their facilitated degradation
  • cell & other
    REGULATION
    induced by by heat shock under the control of the htpr regulatory protein
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS