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FLASH GENE
Symbol DNAJC1 contributors: - updated : 25-07-2006
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 1
HGNC id 20090
Location 10p12.31      Physical location : 22.045.477 - 22.292.650
Synonym symbol(s) DNAJL1, HTJ1, ERdj1
DNA
TYPE functioning gene
STRUCTURE 247.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DNMT2 10p15.1 DNA (cytosine-5-)-methyltransferase 2 VIM 10p13 vimentin ST8SIA-VI 10p13 alpha 2,8-sialyltransferase PTPLA 10p14-p13 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a STAM 10p14-p13 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 LOC340843 10p13 similar to protein of unknown function LOC340893 10p13 similar to protein of unknown function MRC1 10p13 mannose receptor, C type 1 SLC39A12 10p13 solute carrier family 39 (zinc transporter), member 12 CACNB2 10p12 calcium channel, voltage-dependent, beta 2 subunit NOPD1 10p13 nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 ARL8 10p13 ADP-ribosylation factor-like 8 LOC389942 10 similar to Programmed cell death protein 8, mitochondrial precursor (Apoptosis-inducing factor) LOC387635 10 similar to ubiquitin-conjugating enzyme E2 variant 1 isoform a; DNA-binding protein LOC340895 10p12.33 similar to apical early endosomal glycoprotein precursor LOC387636 10 LOC387636 PLXDC2 10p12.33 plexin domain containing 2 LOC220998 10p12.33 similar to Protein C21orf59 NEBL 10p12 similar to Protein C21orf59 LOC387637 10 similar to eukaryotic initiation factor 4B LOC387638 10 LOC387638 LOC387639 10 LOC387639 LOC219689 10p12.33 similar to putative RNA methyltransferase LOC387640 10 similar to RIKEN cDNA E130012A19 MLLT10 10p12 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 DNAJC1 10p12.31 DnaJ (Hsp40) homolog, subfamily C, member 1 LOC340900 10p12.32 similar to Hypothetical protein FLJ10213 LOC338098 10p12 proteasome activator subunit 2 pseudogene LOC389943 10 similar to ribosomal protein L31 BMI1 10p13 B lymphoma MO-MLV insertion region (mouse) C10orf8 10pter-q22.1 chromosome 10 open reading frame 8 SPAG6 10p12-p11.2 sperm associated antigen 6 PIP5K2A 10p11.23 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha FLJ32827 PILB 10p12 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha LOC143371 10p12.31 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene PTF1A 10p12.31 pancreas specific transcription factor, 1a LOC387642 10 similar to RIKEN cDNA 4921522E24 MGC46732 LOC220213 10p12.31 hypothetical protein LOC220213 DKFZP761L0424 ARHGAP21 10p12.31 Rho GTPase activating protein 21 PRTFDC1 10p12.31 phosphoribosyl transferase domain containing 1 MGC26778 FLJ22002 10p12.31 hypothetical protein FLJ22002 GPR158 10p12.31 G protein-coupled receptor 158 MYO3A 10p11.1 myosin IIIA GAD2 10p11.23 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) APBB1IP 10p12.2 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein LOC387643 10 similar to amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; proline-rich protein 73; Rap1-interacting adaptor molecule TPT 10p12.2-p12.1 trans-prenyltransferase SSH3BP1 10p11.2 spectrin SH3 domain binding protein 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinelarge intestinecolon moderately
 liver   moderately
 stomach   highly
Endocrineparathyroid   highly
 thyroid   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
 respiratory tractlarynx  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text umbilical cord (predominantly)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a J domain
  • a MYB-like DNA binding domain
  • a C-terminal cytosolic region of unknown function consisting of two SANT domains separated by a spacer region
  • HOMOLOGY
    interspecies ortholog to rattus Dnajc1 (86.3pc)
    ortholog to murine Dnajc1 (86pc)
    Homologene
    FAMILY
    CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    text
  • nuclear membrane (multi-pass membrane protein)
  • microsomal membrane (multi-pass membrane protein)
  • endoplasmic reticulum lumen
  • basic FUNCTION
  • acting as an ATPase stimulator
  • acting as a Hsp70/Hsc70 protein regulator
  • involved in the negative regulation of proteolysis
  • playing a role in the regulation of protein secretion
  • playing a role in the regulation of transcription
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • unfolded protein
  • alpha1-antichymotrypsin
  • HSPA5
  • cell & other
  • ribosome
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS