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FLASH GENE
Symbol DNAJB9 contributors: mct - updated : 23-12-2013
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 9
HGNC id 6968
Location 7q31.1      Physical location : 108.210.355 - 108.215.292
Synonym name
  • microvascular endothelial differentiation gene 1
  • endoplasmic reticulum DnaJ homolog 4
  • ER-resident protein ERdj4
  • Synonym symbol(s) MDG1, ERdj4, MST049, MSTP049
    DNA
    TYPE functioning gene
    STRUCTURE 5.11 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure a cis-acting element in the MDG1/ERdj4 promoter region, to which XBP1 specifically binds in response to ER stress
    MAPPING cloned Y linked N status inconsistent : contradictory evidence
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2538 - 223 - 2002 11836248
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   highly
    Endocrinepancreas   moderately
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a predicted hydrophobic alpha-helical transmembrane domain of only 11 AAs , which is shorter than reported for most resident ER integral membrane proteins, which are typically 1417 hydrophobic AAs in length
  • DNAJ molecular chaperone homology domain
  • lack the -KDEL sequence found on most resident ER luminal chaperones
  • HOMOLOGY
    interspecies homolog to murine Drajb9
    Homologene
    FAMILY ERdj family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleolus
    text stress induces its translocation to the nucleus
    basic FUNCTION
  • may be a heat shock protein, acting as a cochaperone with an HSP70 protein
  • may be involved in either protein folding or ER-associated degradation
  • DNAJC10 and DNAJB9 play important roles in the ER-associated degradation (ERAD) of unfolded secretory proteins
  • endoplasmic reticulum chaperone co-factor that assists with destruction of misfolded secretory proteins
  • mobile soluble luminal protein that is recruited to the misfolded secretory protein quality control machinery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DNAJB9, DNAJC10 promote turnover of misfolded SFTPC and this activity is dependent on their ability to stimulate HSPA5 ATPase activity
  • associate with the integral membrane protein, DERL1
  • cell & other
    REGULATION
    Other regulated by the IRE1-XBP1 pathway
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS