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FLASH GENE
Symbol DNAJB4 contributors: mct/pgu - updated : 16-03-2011
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 4
HGNC id 14886
Location 1p31.1      Physical location : 78.470.635 - 78.482.993
Synonym name
  • HSP40 homolog
  • heat shock 40 kDa protein 1 homolog
  • human liver DnaJ-like protein
    • Synonym symbol(s) HLJ1, DNAJW, DjB4
    DNA
    TYPE functioning gene
    STRUCTURE 12.36 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DKFZp547I048 1p31.1 hypothetical protein DKFZp547I048 CRYZ 1p31-p22 crystallin, zeta (quinone reductase) LOC388640 1 similar to crystallin, zeta; NADPH:quinone reductase LOC127253 1p31.1 hypothetical protein BC009514 LOC148864 1p31.1 similar to LIM homeo domain transcription factor MGC34032 1p31.1 hypothetical protein MGC34032 LOC388641 1 LOC388641 LOC343221 1p31.1 similar to KIAA0433 protein ACADM 1p31 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain DLSTP 1p31 dihydrolipoamide S-succinyltransferase pseudogene (E2 component of 2-oxo-glutarate complex) RABGGTB 1p31 Rab geranylgeranyltransferase, beta subunit MSH4 1p31 mutS homolog 4 (E. coli) ASB17 1p31.1 ankyrin repeat and SOCS box-containing 17 SIAT7C 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C LOC388642 1 similar to Triosephosphate isomerase (TIM) LOC388643 1 LOC388643 SIAT7E 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E LOC256483 1p31.1 hypothetical LOC256483 PIGK 1p31.1 phosphatidylinositol glycan, class K AK5 1p31 adenylate kinase 5 DKFZP564I052 USP33 1p31.1 ubiquitin specific protease 33 FLJ35093 1p31.1 FLJ35093 protein LOC91624 FUBP1 1p31.1 far upstream element (FUSE) binding protein 1 DNAJB4 1p31.1 DnaJ (Hsp40) homolog, subfamily B, member 4 LOC339425 1p31.1 similar to Nit protein 2 GIPC2 1p31.1 PDZ domain protein GIPC2 LOC388644 1 hypothetical gene supported by AK091757 PTGFR 1p31.1 prostaglandin F receptor (FP) C1orf29 1p31.1 chromosome 1 open reading frame 29 IFI44 1p31.1 interferon-induced protein 44 LOC343295 1p31.1 similar to Nuclear protein SkiP (Ski-interacting protein) (SNW1 protein) (Nuclear receptor coactivator NCoA-62) ELTD1 1p33-p32 EGF, latrophilin and seven transmembrane domain containing 1 LOC149050 1p31.1 similar to phosphoserine aminotransferase isoform 1 LOC343296 1p31.1 similar to Alcohol dehydrogenase class III chi chain (Glutathione-dependent formaldehyde dehydrogenase) (FDH) LOC391049 1 similar to Rda288-prov protein COX6A1P 1p31.1 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene LOC391050 1 similar to ribosomal protein L7 LOC343301 1p31.1 similar to ribosomal protein L10a
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2250 - 337 - 1998 9546042
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal J domain,(AAs 1-67) that mediates interactions with Hsp70 and regulates ATPase activity of Hsp70
  • a glycine and phenylalanine (G/F)-rich region, (positions 68&
    • 65533;141AA) that is disordered and possibly acts as a flexible linker
  • a non-typical caspase-3 cleavage site (MEID) at AA 125&
    • 65533;128
  • C-terminal domain (positions 200&
    • 65533;321) forming a beta-sheet structure involved in substrate binding and presentation
    HOMOLOGY
    interspecies homolog to Drosophila DnaJ-1
    homolog to C.elegans dnj-13
    Homologene
    FAMILY
  • DNAJ/HSP40 protein family
  • subfamily B
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a heat shock protein activity
  • tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis
  • switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP2 promoter
  • tumor suppressor protein closely related to relapse and survival in non-small cell lung cancer (NSCLC) patients
  • promotes UV-induced apoptosis through enhancing JNK and caspase-3 activation in non-small cell lung cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the nuclear protein nucleophosmin (NPM1), forming a multiprotein complex that alters the nucleolar distribution and oligomerization state of NPM1
  • substrate of caspase-3 during the UV-induced apoptotic process
  • association between DNAJB4 and beta-actin, increased by acidic stress, to modulate migration of human lung cancer cells
    • cell & other
    REGULATION
    activated by via enhancer AP1 binding to promoter YY1 and the coactivator, EP300, through DNA bending and multiprotein complex formation
    induced by heat shock
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS