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FLASH GENE
Symbol DNAJB4 contributors: mct/pgu - updated : 16-03-2011
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 4
HGNC id 14886
Location 1p31.1      Physical location : 78.470.635 - 78.482.993
Synonym name
  • HSP40 homolog
  • heat shock 40 kDa protein 1 homolog
  • human liver DnaJ-like protein
  • Synonym symbol(s) HLJ1, DNAJW, DjB4
    DNA
    TYPE functioning gene
    STRUCTURE 12.36 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2250 - 337 - 1998 9546042
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal J domain,(AAs 1-67) that mediates interactions with Hsp70 and regulates ATPase activity of Hsp70
  • a glycine and phenylalanine (G/F)-rich region, (positions 68&
  • 65533;141AA) that is disordered and possibly acts as a flexible linker
  • a non-typical caspase-3 cleavage site (MEID) at AA 125&
  • 65533;128
  • C-terminal domain (positions 200&
  • 65533;321) forming a beta-sheet structure involved in substrate binding and presentation
    HOMOLOGY
    interspecies homolog to Drosophila DnaJ-1
    homolog to C.elegans dnj-13
    Homologene
    FAMILY
  • DNAJ/HSP40 protein family
  • subfamily B
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a heat shock protein activity
  • tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis
  • switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP2 promoter
  • tumor suppressor protein closely related to relapse and survival in non-small cell lung cancer (NSCLC) patients
  • promotes UV-induced apoptosis through enhancing JNK and caspase-3 activation in non-small cell lung cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the nuclear protein nucleophosmin (NPM1), forming a multiprotein complex that alters the nucleolar distribution and oligomerization state of NPM1
  • substrate of caspase-3 during the UV-induced apoptotic process
  • association between DNAJB4 and beta-actin, increased by acidic stress, to modulate migration of human lung cancer cells
  • cell & other
    REGULATION
    activated by via enhancer AP1 binding to promoter YY1 and the coactivator, EP300, through DNA bending and multiprotein complex formation
    induced by heat shock
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS