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FLASH GENE
Symbol DNAJB12 contributors: mct - updated : 01-09-2011
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 12
HGNC id 14891
Location 10q22.1      Physical location : 74.092.587 - 74.114.907
Synonym name DnaJ homolog subfamily B member 12
Synonym symbol(s) FLJ20027, DJ10
DNA
TYPE functioning gene
STRUCTURE 22.32 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PCBD 10q22 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) UNC5B 10q22.2 unc-5 homolog B (C. elegans) SLC29A3 10q22.2 solute carrier family 29 (nucleoside transporters), member 3 CDH23 10q22.3 cadherin related 23 PSAP 10q22.1 prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) CHST3 10q22.1 carbohydrate (chondroitin 6) sulfotransferase 3 SPOCK2 10pter-q25.3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 CGI-18 10pter-q25.3 CGI-18 protein LOC119504 10q22.2 hypothetical protein LOC119504 RTP801 DNAJB12 10q22.3 DnaJ (Hsp40) homolog, subfamily B, member 12 CBARA1 10q22.3 calcium binding atopy-related autoantigen 1 C10orf42 10q22.2 chromosome 10 open reading frame 42 FLJ39116 10q22.2-q22.3 oncoprotein induced transcript 3 PLA2G13 10q22.3 phospholipase A2, group XIII LOC148854 10q22.3 similar to 60S ribosomal protein L17 (L23) P4HA1 10q22.3 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I NUDT13 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 HSGT1 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 DNAJC9 10q22.3 DnaJ (Hsp40) homolog, subfamily C, member 9 MRPS16 10q22.1 mitochondrial ribosomal protein S16 LOC118491 10q22.3 tetratricopeptide repeat-containing protein ANXA7 10q21.1-q21.2 annexin A7 ZMYND17 10q22.3 zinc finger, MYND domain containing 17 PPP3CB 10q22.3 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) C10orf29 MYOZ1 10q22.1 myozenin 1 SYNPO2L 10q22.3 synaptopodin 2-like LOC118704 10q22.3 similar to ARF GTPase-activating protein LOC389978 10 similar to Ribosome biogenesis protein BMS1 homolog GLUDP3 10q22.1 glutamate dehydrogenase pseudogene 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 4377 41 375 - 2011 21148293
9 - 3215 41 375 - 2011 21148293
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   moderately
Cardiovascularheart   moderately
Digestiveliver   moderately
Endocrineparathyroid   highly
Nervousbrain   highly
Reproductivefemale systemuterus  highly
Respiratorylung   moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved 70-amino acid J domain, usually at the N terminus
  • a glycine/phenylalanine (G/F)-rich region
  • and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain
  • HOMOLOGY
    interspecies ortholog to murine Dnajb12
    homolog to Drosophila CG3061
    homolog to C.elegans dnj-1
    Homologene
    FAMILY DNAJ/HSP40 family of proteins
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text membrane-associated
    basic FUNCTION
  • regulate molecular chaperone activity by stimulating ATPase activity
  • ER-localized single membrane-spanning protein carrying a J-domain facing the cytosol
  • a novel mammalian ER-localized J-protein that plays a vital role in the quality control of membrane proteins
  • play a role in control of CFTR folding efficiency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • able to bind Hsc70 and thus can recruit Hsc70 to the ER membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS