Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DNAJA3 contributors: mct/pgu - updated : 16-03-2010
HGNC name DnaJ (Hsp40) homolog, subfamily A, member 3
HGNC id 11808
Location 16p13.3      Physical location : 4.475.857 - 4.506.773
Synonym name
  • Drosophila tumor suppressor protein Tid56 (tumorous imaginal discs) homolog
  • tumorous imaginal discs 1
  • hepatocellular carcinoma-associated antigen 57
  • Synonym symbol(s) hTid-1,TID1, FLJ45758
    DNA
    TYPE functioning gene
    STRUCTURE 30.92 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure several transcription binding sites for AP-1, PEA3, 2F, NFKB
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2663 52 453 ubiquitous 2011 21242965
  • also called TID-1S
  • suppressor of apoptosis
  • its expression in gliomas may contribute to their susceptibility to cell death triggers
  • essential regulatory component of MST1R signaling
  • 12 - 2728 52.5 480 - 2011 21242965
  • isoform 1, variant TID-1L
  • increases apoptosis triggered by TNF-alpha
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal consensus mitochondrial processing sequence
  • one CR-type zinc finger
  • J domain (highly conserved tetrahelical domain that binds to Hsp chaperones
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila tumor suppressor proteinTid56 (tumorour imaginal discs)
    homolog to murine Dnaja3 (87.3pc)
    homolog to Drosophila l(2)tid
    homolog to C.elegans dnj-10
    homolog to rattus Dnaja3 (87.5pc)
    Homologene
    FAMILY
  • DNAJ/HSP40 family of chaperones
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    text identified in the mammalian cytosol
    basic FUNCTION
  • playing a role as a repressor of Ikappa B kinase beta subunit
  • acting as modulators of cytochrome c release from the mitochondria and caspase 3 activation
  • modulating IFNG-mediated transcriptional activity
  • playing a crucial role for mitochondrial biogenesis, at least in part, through its chaperone activity on POLGA
  • involved in multiple intracellular signaling pathways such as apoptosis induction, cell proliferation, and survival
  • may act as a chaperone to facilitate the folding, processing and maturation of Epstein-Barr virus-encoded Barf1 protein
  • modulates apoptotic signal transduction or effector structures within the mitochondrial matrix
  • regulator of TP53-mediated apoptosis
  • modulator of JAK-STAT pathway
  • co-chaperone of the Hsp70 family of proteins, regulating a number of cellular signaling proteins including several involved in tumorigenic and apoptotic pathways
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to human papilloma virus type 16E7 oncoprotein
  • interacts with the TRK receptor tyrosine kinases in an activity-dependent manner to facilitate Trk-dependent intracellular signaling
  • interacting with JAK2, IFNGR2, HSPA1A, HSPA9B, RASA1
  • forming a complex with TP53 under hypoxic conditions that directs TP53 translocation to the mitochondria and the subsequent initiation of the mitochondrial apoptosis pathway
  • binds to unphosphorylated MST1R and becomes dissociated from the receptor upon HGF stimulation
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeted inhibition of DNAJA3 may be a useful therapeutic in the management of MST1R-dependent malignancies
    cancer  
    therapies designed to enhance DNAJA3's function in promoting mitochondrial localization of TP53 and apoptosis could be an effective therapy in many cancers
    ANIMAL & CELL MODELS