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FLASH GENE
Symbol DNAJA1 contributors: npt/ - updated : 06-05-2005
HGNC name DnaJ (Hsp40) homolog, subfamily A, member 1
HGNC id 5229
Location 9p21.1      Physical location : 33.025.208 - 33.039.062
Synonym name
  • heat shock protein DNAJ-like 2
  • DnaJ protein homolog 2
  • heat shock 40 kDa protein 4
  • neural precursor cell expressed, developmentally down-regulated 7
  • Synonym symbol(s) HSPF4, HSJ2, DJ2, HDH2, DNAJ1, HDJ2 , HSDJ, NEDD7
    DNA
    TYPE functioning gene
    STRUCTURE 13.85 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RIG-I 9p12 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide TOPORS 9p21 topoisomerase I binding, arginine/serine-rich NDUFB6 9p13.2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa TAF1L 9p13.3 TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa LOC389710 9 similar to hypothetical protein (L1H 3 region) - human LOC392302 9 similar to argininosuccinate synthetase APTX 9p13.3 aprataxin DNAJA1 9p13-p12 DnaJ (Hsp40) homolog, subfamily A, member 1 SMU-1 9p12 homolog of C. elegans smu-1 B4GALT1 9p13 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 SPINK4 9p12 serine protease inhibitor, Kazal type 4 BAG1 9p12 BCL2-associated athanogene HSPC177 NFX1 9p12 nuclear transcription factor, X-box binding 1 AQP7 9p13 aquaporin 7 AQP3 9p13 aquaporin 3 NOL6 9p13.2 nucleolar protein family 6 (RNA-associated) bA255A11.3 9p12 FLJ35740 pseudogene LOC389711 9 similar to hypothetical protein DKFZp434F1719
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1538 - 397 - Hanai (2003)
    localized to the nucleus
    - splicing - - 231 - Hanai (2003)
  • observed throughout the cell, consistent with the elimination of a nuclear localization signal sequence as a result of the alternative splicing
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   moderately
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a J domain
  • a DR domain
  • conjugated LipoP , Other
    HOMOLOGY
    interspecies homolog to murine Dnaja1
    homolog to Drosophila CG8863
    homolog to C.elegans dnj-12
    homolog to yeast S.cerevisiae HSJ2
    Homologene
    FAMILY
    CATEGORY chaperone/stress , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text
  • colocalizing with Hsp70 (HSPA*),DNAJA2,BAG1 after heat shock
  • membrane-bound
  • identified in the mammalian cytosol (Abdul 2002)
  • basic FUNCTION
  • transport of certain proteins into the mitochondria and endoplasmic reticulum
  • positive cochaperone of Hsp70
  • having a heat shock protein activity
  • with DNAJA2, cause a decrease in the amount of KCNH2 complexed with Hsc70, indicating a preferential degradation of the complex (Walker 2010)
  • role for the DJA proteins in regulating degradation suggesting that they act at a critical point in secretory pathway quality control (Walker 2010)
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS cellular trafficking transport , mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS