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FLASH GENE

Symbol

DNAI2

contributors: mct/npt - updated : 24/11/2008

HGNC name	dynein, axonemal, intermediate chain 2
HGNC id	18744

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ICS11 immotile cilia syndrome 11
Location	17q25      Physical location : 72.270.385 - 72.311.022
Synonym name	dynein intermediate chain 2
	dynein, axonemal, intermediate polypeptide 2

DNA

TYPE	functioning gene
STRUCTURE	40.61 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 14 - 2299 69 605 - Pennarun (2000)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus         male system testis       Respiratory respiratory tract trachea

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Respiratory epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a tyrosine-kinase and a casein-kinase phosphorylation sites in the N terminal region
	five WD-repeats
	a PKC/CKII phosphorylation site in the C terminus

HOMOLOGY

interspecies

ortholog to Chlamydomonas reinhardtii IC69

Homologene

FAMILY

dynein intermediate chain

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	cilia in respiratory tract
	flagella of spermatozoa

basic FUNCTION	dynein intermediate chain, outer arm, part of the dynein complex of respiratory cilia
	may be playing plays a role in outer dynein arms assembly and function in cilia and flagella
	essential for outer dynein arms assembly throughout the ciliary axoneme

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , reproduction/sex

text	cilia movements and left-right (L/R) asymetry
	sperm motility

PATHWAY

metabolism

signaling

a component

axonema of cilia and flagella

INTERACTION

DNA

RNA

small molecule

protein

tubulin

cell & other

microtubules

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICS11

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS