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FLASH GENE
Symbol DNAH17 contributors: mct - updated : 26-08-2019
HGNC name dynein, axonemal, heavy polypeptide 17
HGNC id 2946
Corresponding disease
SPGF39 Spermatogenic failure 39
Location 17q25.3      Physical location : 76.419.778 - 76.573.476
Synonym name
  • ciliary dynein heavy chain 17
  • ciliary dynein heavy chain-like protein 1
  • dynein light chain 2, axonemal
  • Synonym symbol(s) DNEL2, DNAHL1
    DNA
    TYPE functioning gene
    STRUCTURE 153.74 kb     90 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map cen - TK1 - D17S836 - D17S784 - GAA - (ACTG1 ,P4HB ,P4HB ) - DNAH17 - qter
    Authors Milisav (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    90 - 13725 - 4462 - 1998 9545504
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • outer dynein arm heavy chain having ATPase activity
  • involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle apparatus
  • CELLULAR PROCESS cell cycle, division
    cell communication
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component axonemal constituent (outer arm)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other interacting with microtubules
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF39
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a promising biomarker for tumor thrombosis in HCC patients
  • Therapy target
    ANIMAL & CELL MODELS