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FLASH GENE
Symbol DNAH10 contributors: mct - updated : 22-09-2021
HGNC name dynein, axonemal, heavy polypeptide 10
HGNC id 2941
Corresponding disease
MMAFS6 multiple morphological abnormalities of the sperm flagella syndrome 6
Location 12q24.31      Physical location : 124.247.041 - 124.420.265
Synonym name
  • ciliary dynein heavy chain 10
    • Synonym symbol(s) FLJ38262, FLJ43486, FLJ43808, KIAA2017, SPGF56
    DNA
    TYPE functioning gene
    STRUCTURE 173.73 kb     75 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    79 - 14039 - 4589 - 2016 26517670
    79 - 13716 - 4471 - 2016 26517670
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  predominantly Homo sapiens
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Dnahc10
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized to the entire sperm flagellum of control spermatozoa
    • basic FUNCTION
  • inner dynein arm heavy chain, having ATPase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MMAFS6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in inflammatory lesions of psoriasis when compared to unaffected skin (
    constitutional germinal mutation      
    that may play a role in regulating HDLc levels '
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dnah10-mutated male mice were sterile and displayed a typical MMAF phenotype, including completely immotile sperm and abnormal flagella