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FLASH GENE
Symbol DMTF1 contributors: mct/npt/pgu - updated : 18-08-2009
HGNC name cyclin D binding myb-like transcription factor 1
HGNC id 14603
Location 7q21.1      Physical location : 86.781.676 - 86.825.646
Synonym name cyclin D-binding Myb-like protein
Synonym symbol(s) CCNDMP1L, DMP1, DMTF, FLJ41265, hDMP1, FLJ25188, FLJ76054
DNA
TYPE functioning gene
STRUCTURE 43.97 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
SEMA3A 2q37-qter sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A HMG17P1 7q11-q21 high-mobility group (nonhistone chromosomal) protein 17 pseudogene 1 LOC285984 7q21.12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) SEMA3D 7q21.12 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D LOC392067 7 similar to dynein, cytoplasmic, light peptide GRM3 7q21.1-q21.2 glutamate receptor, metabotropic 3 FLJ31340 7q21.13 hypothetical protein FLJ31340 DMTF1 7q21.1 cyclin D binding myb-like transcription factor 1 C7orf23 7q21.1-q21.2 chromosome 7 open reading frame 23 TP53AP1 7q21.1 TP53 activated protein 1 CROT 7q21.1 carnitine O-octanoyltransferase ABCB4 7q21.1 ATP-binding cassette, sub-family B (MDR/TAP), member 4 ABCB1 7q21.1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 RPIB9 7q21.13 Rap2-binding protein 9 MCFP 7q21.13 mitochondrial carrier family protein ASK 7q21.3 mitochondrial carrier family protein ADAM22 7q21.1 a disintegrin and metalloproteinase domain 22 SRI 7q21.1 sorcin FLJ23153 7q21.13 likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein LOC392068 7 similar to CSRP2 binding protein isoform a; CRP2 binding protein; cysteine rich protein 2 binding protein; CRP2 binding partner LOC392069 7 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) LOC219558 7q21.13 similar to elongation factor 1 alpha FLJ32110 7q21.13-q21.2 hypothetical protein FLJ32110 MGC26647 7q21.13 hypothetical protein MGC26647 STEAP 7q21 six transmembrane epithelial antigen of the prostate STEAP2 7q21 six transmembrane epithelial antigen of prostate 2 FLJ21062 7q21.2 hypothetical protein FLJ21062 LOC85865 7q21.2 hypothetical protein BC004923
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3801 - 760 - 2003 12917399
- - 3933 - 272 - 2003 12917399
antagonizes DMTF1 alpha activity
- - 3972 - 285 - 2003 12917399
17 - 3684 - 672 - 2003 12917399
20 - 4052 - 760 - 2003 12917399
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three imperfect myb repeats
  • flanked by N and C terminal acidic transactivating domains
  • HOMOLOGY
    Homologene
    FAMILY
  • DMTF1 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in the spliceosome
    basic FUNCTION
  • potential inhibitor of cell cycle S phase entry
  • putative up or downregulated MYC target gene, regulating cell proliferation
  • Ras-activated transcription factor that can stimulate CDKN2A transcription to promote TP53-dependent cell arrest
  • physiological regulator of the Arf-TP53 pathway
  • RAS/ERBB2-activated haplo-insufficient tumor suppressor that activates the CDKN2A/TP53 pathway of cell-cycle arrest
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by cellular DMTF1 isoform levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS