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FLASH GENE
Symbol DMKN contributors: mct - updated : 30-01-2013
HGNC name dermokine
HGNC id 25063
Location 19q13.13      Physical location : 35.988.118 - 36.004.560
Synonym name
  • hypothetical gene ZD52F10
  • dermokine beta-1
  • dermokine beta-2
  • Synonym symbol(s) UNQ729, SK89, ZD52F10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.44 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 613 - 90 . low mRNA expression level in the epidermis . with beta and gamma isoforms share an epidermis-restricted expression pattern 2011 21423773
  • dermokin alpha
  • several N-myristoylation sites
  • extracellular
  • alpha isoform representing the C terminus of the beta isoform
  • 16 - 1946 - 476 . strongly detected in the epidermis . with alpha and gamma isoforms share an epidermis-restricted expression pattern 2011 21423773
  • dermokin beta
  • two conserved cysteine residues, and a conseved potential N-glycosylation site and several N-myristoylation sites
  • extracellular
  • alpha isoform representing the C terminus of the beta isoform
  • 18 - 1913 - 465 - 2011 21423773
  • isoform beta 2
  • HSPA5 is a dermokine-beta-associated protein (impairs ERK signaling through direct binding to HSPA5)
  • - - 1471 - 386 - 2011 21423773
    - - 1507 - 398 - 2011 21423773
    isoform gamma 2
    - - 1062 - 137 - 2011 21423773
    - - 1734 - 369 . with beta and alpha isoforms share an epidermis-restricted expression pattern 2011 21423773
  • isoform gamma 1
  • similar to dermokine beta in its 5'-end, but comprises an alternative exon encoding a stop codon and a functional polyadenylation signal
  • extracellular
  • 12 - 964 - 189 intracellular and ubiquitous 2011 21423773
  • dermokin delta
  • intracellular variant
  • direct interaction between RAB5A and DMKN delta (activates RAB5A function and thus is involved in the early endosomal trafficking)
  • 17 - 1865 - 449 - 2011 21423773
    isoform beta 1
  • HSPA5 is a dermokine-beta-associated protein (impairs ERK signaling through direct binding to HSPA5)
  • - - 1621 - 436 - 2011 21423773
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon  
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Reproductivefemale systemovary   
     female systemuteruscervix  
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum spinosum 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • rich in glycine and serine residues
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • major keratinocyte cell envelope protein
  • expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • Serum DMKN-isofrorm beta/gamma is the most promising of the existing tumor biomarkers for the diagnosis of early-stage colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS