basic FUNCTION
| dosage suppressor of MCK1 |
|
playing a role in repair of DNA double-strand breaks during meiosis and in maintaining the ploidy of meiotic chromosomes |
|
essential for meiotic homologous recombination |
|
its function is restricted to meiosis |
|
DNA strand exchange activity of DMC1 is probably indispensable for repair of DNA double-strand breaks during meiosis and for maintaining the ploidy of meiotic chromosomes |
|
RAD54B synergizes with the DMC1 recombinase to mediate inter-homologue recombination during meiosis |
|
RAD51 recombinase and the meiosis-specific DMC1 recombinase promote the formation of strand-invasion products (D-loops) between homologous molecules |
|
during meiosis, the RAD51 recombinase and its meiosis-specific homolog DMC1 mediate DNA strand exchange between homologous chromosomes |
|
DMC1 dominance in promoting strand exchange between homologs involves repression of RAD51 strand-exchange activity |
|
both RAD51 and DMC1 are required for interhomolog recombination during meiosis |
|
DMC1 and RAD51 are conserved recombinases that catalyze homologous recombination, but unlike RAD51, presynaptic filament stabilization achieved via ATP hydrolysis attenuation does not lead to any enhancement of DMC1-catalyzed homologous DNA pairing and strand exchange |
|
RAD51 and DMC1 form partially overlapping co-foci |
|
meiosis-specific DNA strand exchange protein, that promotes the formation of DNA strand invasion products (joint molecules) between homologous molecules in a fashion similar to RAD51 |
|
DMC1 and RAD51 are essential eukaryotic recombinases that mediate homologous chromosome pairing during homologous recombination |