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FLASH GENE
Symbol DMC1 contributors: mct - updated : 25-10-2017
HGNC name DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
HGNC id 2927
Location 22q13.1      Physical location : 38.914.953 - 38.966.189
Synonym name
  • disrupted meiotic cDNA1, yeast, homolog of
  • meiotic recombination protein DMC1/LIM15 homolog
  • Synonym symbol(s) DMC1H, LIM15, MGC150472, MGC150473
    DNA
    TYPE functioning gene
    STRUCTURE 61.13 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2281 - 340 - 2013 23182424
    11 - 2082 - 285 - 2013 23182424
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain involved in octamer formation and DNA binding
  • highly conserved WVPP motif critical for DMC1 interaction but dispensable for RAD51 association
  • a Walker A motif with a conserved lysine critical for ATP binding which is required for presynaptic filament formation
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae
    homolog to E.coli Rec-A like gene
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • dosage suppressor of MCK1
  • playing a role in repair of DNA double-strand breaks during meiosis and in maintaining the ploidy of meiotic chromosomes
  • essential for meiotic homologous recombination
  • its function is restricted to meiosis
  • DNA strand exchange activity of DMC1 is probably indispensable for repair of DNA double-strand breaks during meiosis and for maintaining the ploidy of meiotic chromosomes
  • RAD54B synergizes with the DMC1 recombinase to mediate inter-homologue recombination during meiosis
  • RAD51 recombinase and the meiosis-specific DMC1 recombinase promote the formation of strand-invasion products (D-loops) between homologous molecules
  • during meiosis, the RAD51 recombinase and its meiosis-specific homolog DMC1 mediate DNA strand exchange between homologous chromosomes
  • DMC1 dominance in promoting strand exchange between homologs involves repression of RAD51 strand-exchange activity
  • both RAD51 and DMC1 are required for interhomolog recombination during meiosis
  • DMC1 and RAD51 are conserved recombinases that catalyze homologous recombination, but unlike RAD51, presynaptic filament stabilization achieved via ATP hydrolysis attenuation does not lead to any enhancement of DMC1-catalyzed homologous DNA pairing and strand exchange
  • RAD51 and DMC1 form partially overlapping co-foci
  • meiosis-specific DNA strand exchange protein, that promotes the formation of DNA strand invasion products (joint molecules) between homologous molecules in a fashion similar to RAD51
  • DMC1 and RAD51 are essential eukaryotic recombinases that mediate homologous chromosome pairing during homologous recombination
  • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of synaptonemal complexes
  • component of mixed complexes with RAD51
  • evolutionarily conserved PSMC3IP/MND1 complex is a key cofactor for the meiosis-specific recombinase DMC1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • like RAD51, could interact with the C-terminal region of BRCA2
  • interacting with RAD54B (RAD54B binding may affect the quaternary structure of DMC1)
  • functional cooperation is dependent on complex formation between DMC1 and RAD51AP1 and distinct epitopes in RAD51AP1 mediate interactions with RAD51 and DMC1
  • works in conjunction with RAD51 in forming meiotic interhomologue crossovers, whereas RAD51 acting alone may be more adept at mediating DSB repair using the sister chromatid as an information donor
  • SFPQ may function as an activator for the meiosis-specific recombinase DMC1 in higher eukaryotes
  • RAD51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis
  • MEIOB appeared to be dispensable for the initial loading of recombinases but was required to maintain a proper number of RAD51 and DMC1 foci beyond the zygotene stage
  • BRCA2 interacts directly with both RAD51 and DMC1 (pMID: 26976601)
  • suggesting a sex-specific function for the two proteins)
  • SYCP3 functions in meiotic homologous recombination biased to interhomologous chromosomes, by regulating the strand invasion activities of the RAD51 and DMC1 recombinases
  • cell & other associated with mouse meiotic chromosome core and synaptonemal complexes
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS