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FLASH GENE
Symbol DMBX1 contributors: mct - updated : 26-04-2017
HGNC name diencephalon/mesencephalon homeobox 1
HGNC id 19026
Location 1p33      Physical location : 46.972.667 - 46.979.884
Synonym name
  • orthodenticle homolog 3 (Drosophila)
  • paired-like homeobox protein DMBX1-like
  • homeoprotein MBX
  • Synonym symbol(s) HGNC19026, MBX, PAXB, OTX3
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 24.39 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2896 41 382 - 2002 12142024
    4 - 2881 40 377 - 2002 12142024
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalon   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus LOC313512
    homolog to murine Dmbx1
    Homologene
    FAMILY bicoid subfamily of homeodomain containing transcription factor
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in brain and sense organ development
  • involved in the development of the neural network for the signaling, being essential for various actions of agouti-related protein (AGRP)
  • plays a role in normal regulation of energy homeostasis and behavior
  • brain-specific homeodomain transcription factor expressed primarily during embryogenesis
  • in the adult lateral parabrachial nucleus (LPB), is required for the long-lasting orexigenic effect of AGRP via the neural circuitry involving calcitonin gene-related peptide neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • VSX2 gene expression requires active FGF signaling and this in turn suppresses DMBX1 expression and maintains cells in an undifferentiated, proliferative retinal progenitor cells (RPCs) state
  • antagonistic relationship between VSX2 and DMBX1 to control retinal progenitor cells (RPCs) proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS