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FLASH GENE
Symbol DMAP1 contributors: mct - updated : 18-05-2011
HGNC name DNA methyltransferase 1 associated protein 1
HGNC id 18291
Location 1p34.1      Physical location : 44.679.124 - 44.686.351
Synonym name
  • TSG101-interacting protein
  • DNMT1 associated protein 1
  • MAT1-mediated transcriptional repressor
  • Synonym symbol(s) KIAA1425, DNMAP1, DNMTAP1, EAF2, FLJ11543, SWC4, DKFZp686L09142, MMTR
    DNA
    TYPE functioning gene
    STRUCTURE 7.23 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F JMJD2 1p34.1 jumonji domain containing 2 SIAT6 1p34.1 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) ARTN 1p32-p31.3 artemin IPO13 1p34.1 importin 13 DPH2L2 1p34 diptheria toxin resistance protein required for diphthamide biosynthesis-like 2 (S. cerevisiae) ATP6V0B 1p32.3 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' B4GALT2 1p34-p33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 MGC45441 1p34.1 hypothetical protein MGC45441 SLC6A9 1p33 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 LOC391034 1 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 FLJ40160 1p34.1 hypothetical protein FLJ40160 LOC128208 1p34.1 similar to dJ675G8.1 (novel zinc finger protein) DMAP1 1p34 DNA methyltransferase 1 associated protein 1 PRNPIP 1p32 prion protein interacting protein FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1784 52.9 467 - 2000 10888872
    11 - 1603 52.9 467 - 2000 10888872
    11 - 1563 52.9 467 - 2000 10888872
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative nuclear localizatio
  • a predicted coiled coil domain that may interact with stathmin
  • a Myb-like DNA binding domain
  • a SB(steadiness box) domain
  • a UEV (ubiquitin e2 variant) domain required for the interaction of the complex with ubiquitin
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY ubiquitin-conjugating enzyme family, UEV subfamily
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the repression or activation of transcription
  • regulator of vesicular trafficking process
  • required for the sorting of endocytic (EGF receptors) cargos
  • co-repressor that inhibits TFIIH-mediated transcriptional activity via interaction with MNAT1
  • may be involved in cell growth and differentiation
  • plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity
  • required for inhibition of CAK kinase-mediated CDK1 phosphorylation
  • has additional roles in genomic stability
  • involved in the regulation of cell cycle progression as an intrinsic negative regulator of CAK that regulates mitotic cell cycle progression
  • cell cycle regulation properties of DMAP1 are strictly related to its expression level, and DMAP1 protein has a dose-dependent anti-proliferative effect on somatic cells
  • CELLULAR PROCESS nucleotide, chromatin organization, methylation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • component of the NuA4 histone acetyltransferase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HDAC2-DNMT1
  • corepressor TSG101
  • facilitating the nuclear localization of C19orf2 and its corepressor activity in a dose-dependent manner by interacting with the CC domain of C19orf2
  • interacts with GGA1 and GGA3
  • interacts with PDCD6IP/AIP1
  • activates DNMT1 preferentially at sites of homologous recombination repair
  • intrinsic negative cell cycle regulator that modulates the CAK kinase activity via interaction with MNAT1 (the coiled-coil domain in the middle of MNAT1 interacts with the C-terminal half of DMAP1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS