Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DLX4 contributors: mct - updated : 21-02-2012
HGNC name distal-less homeobox 4
HGNC id 2917
Location 17q21.33      Physical location : 48.046.561 - 48.052.322
Synonym name
  • beta protein 1
  • distal-less homeo box 7
  • distal-less homeo box 9
  • Synonym symbol(s) DLX7, DLX8 , DLX9, BP1,
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text clustering with DLX3 (? and seven)
    STRUCTURE 5.76 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GALGT2 17q21.3 beta 1,4 N-acetylgalactosaminyltransferase GNGT2 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 NESH 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 PHOSPHO1 17q21.32 phosphatase, orphan 1 LOC124871 17q21.33 hypothetical gene LOC124871 KIAA0924 17q21.32 hypothetical gene LOC124871 PHB 17q21.3 prohibitin LOC388400 17 similar to Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) NGFR 17q21.31 nerve growth factor receptor (TNFR superfamily, member 16) NXPH3 17q21.31 neurexophilin 3 SPOP 17q22 speckle-type POZ protein SLC35B1 17q21.3-q22 solute carrier family 35, member B1 LOC81558 17q21.33 C/EBP-induced protein MYST2 17q21.32 MYST histone acetyltransferase 2 TAC4 17 tachykinin 4 (hemokinin) LOC124865 17q21.33 similar to ribosomal protein P0-like protein; 60S acidic ribosomal protein PO; ribosomal protein, large, P0-like DLX4 17q21-q22 distal-less homeobox 4 DLX3 17q21.3-q22 distal-less homeo box 3 ITGA3 17q22-q23 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) PDK2 17q21.3 pyruvate dehydrogenase kinase, isoenzyme 2 LOC201191 17q21.33 hypothetical protein LOC201191 PPP1R9B 17q21-q22 protein phosphatase 1, regulatory subunit 9B, spinophilin SGCA 17q21 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) HILS1 17q21.33 spermatid-specific linker histone H1-like protein COL1A1 17q21.31-q22.15 collagen, type I, alpha 1 FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2012 - 240 - 1997 9073066
    2 - 1405 - 168 - 1997 9073066
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Hearing/Equilibriumearinner   
    Skin/Tegumentskin    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier liningendometrium  
    cell lineage erythroid cells
    cell lines predominantly in leukemia and cancer cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text pregnancy, extra-embryonic tissues such as placenta (highly)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    helix-turn-helix, DNA binding domain
    HOMOLOGY
    interspecies homolog to Drosophila distal less Dlx4
    Homologene
    FAMILY distal-less homeobox family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in forebrain and craniofacial development
  • required for the transcriptional control of genes important for endometrial cell differentiation
  • may regulate BCL2 and MYC expression
  • transcription factor that is essential for early development
  • important upstream factor in the carcinogenic pathway of prostate cancer
  • may possess properties of onco-proteins that promote tumor progression, invasion, and metastasis, representing a putative signature marker for inflammatory breast cancer and tumor aggressiveness
  • transcription factor that is absent from most normal adult tissues, but is expressed in a wide variety of malignancies
  • having the ability to counteract key transcriptional control mechanisms of the TGFB1 cytostatic program, which could explain, in part, the resistance of tumors to the antiproliferative effect of TGFB1
  • plays an important role in epithelial-mesenchymal interactions during embryonic and placental development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • inhibited TGFB1-mediated induction of CDKN2B and CDKN1A expression
  • bound and prevented SMAD4 from forming complexes with SMAD2 and SMAD3, but not with Sp1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS