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FLASH GENE
Symbol DLX4 contributors: mct - updated : 21-02-2012
HGNC name distal-less homeobox 4
HGNC id 2917
Location 17q21.33      Physical location : 48.046.561 - 48.052.322
Synonym name
  • beta protein 1
  • distal-less homeo box 7
  • distal-less homeo box 9
  • Synonym symbol(s) DLX7, DLX8 , DLX9, BP1,
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text clustering with DLX3 (? and seven)
    STRUCTURE 5.76 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2012 - 240 - 1997 9073066
    2 - 1405 - 168 - 1997 9073066
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Hearing/Equilibriumearinner   
    Skin/Tegumentskin    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier liningendometrium  
    cell lineage erythroid cells
    cell lines predominantly in leukemia and cancer cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text pregnancy, extra-embryonic tissues such as placenta (highly)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    helix-turn-helix, DNA binding domain
    HOMOLOGY
    interspecies homolog to Drosophila distal less Dlx4
    Homologene
    FAMILY distal-less homeobox family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in forebrain and craniofacial development
  • required for the transcriptional control of genes important for endometrial cell differentiation
  • may regulate BCL2 and MYC expression
  • transcription factor that is essential for early development
  • important upstream factor in the carcinogenic pathway of prostate cancer
  • may possess properties of onco-proteins that promote tumor progression, invasion, and metastasis, representing a putative signature marker for inflammatory breast cancer and tumor aggressiveness
  • transcription factor that is absent from most normal adult tissues, but is expressed in a wide variety of malignancies
  • having the ability to counteract key transcriptional control mechanisms of the TGFB1 cytostatic program, which could explain, in part, the resistance of tumors to the antiproliferative effect of TGFB1
  • plays an important role in epithelial-mesenchymal interactions during embryonic and placental development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • inhibited TGFB1-mediated induction of CDKN2B and CDKN1A expression
  • bound and prevented SMAD4 from forming complexes with SMAD2 and SMAD3, but not with Sp1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS