basic FUNCTION
| notch receptor ligand playing a role in the Notch signaling pathway |
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activating NOTCH1 and NOTCH4 |
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is essential for embryonic vascular development and arteriogenesis |
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may be involved in the tumor growth, via its action through the Notch signaling pathway |
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may contribute to vascular differentiation and inhibition of the angiogenic response by regulating multiple receptor pathways |
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vascular-specific Notch ligand critical to normal vascular development |
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indispensable in thymic environment specific for T cell development |
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DLL4 and Jagged1 have opposing effects on angiogenesis |
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unique properties of DLL4 in supporting the combined T lineage and specific myeloid-lineage outcomes that underpin its function within the thymus |
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suppresses effector cell proliferation and enhances Th2 memory cell proliferation |
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DLL4/Notch signaling inhibits human terminal megakaryocytic differentiation |
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essential for the formation of mature vasculature ( |
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specific role for DLL4 in the formation of bone marrow-derived pericyte/vascular smooth muscle cell (vSMC) |
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DLL1- and DLL4-mediated notch signaling are required for homeostasis of intestinal stem cells |
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DLL4 is directly activated by FOXN4 via phylogenetically conserved enhancers and DLL4 can partly mediate the FOXN4 function by serving as a major NOTCH1 ligand to expand the progenitor pool and limit photoreceptor production |
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role for DLL4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis |
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DLL4-NOTCH1 axis promotes potentially sustained macrophage activation via a positive feedback loop—a vicious cycle that represents mechanisms for uncontrolled macrophage activation typical of chronic inflammatory diseases |
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specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow |
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has an essential role in vascular development and angiogenesis |
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DLL4 and JAG1 promote tumour growth by modulating tumour angiogenesis via different mechanisms |