Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DLL1 contributors: mct - updated : 06-05-2016
HGNC name delta-like 1 (Drosophila)
HGNC id 2908
Location 6q27      Physical location : 170.591.295 - 170.599.697
Synonym name
  • delta-like 1 protein
  • H-Delta-1
  • Drosophila Delta homolog 1
  • Synonym symbol(s) DELTA1, DL1, Delta, Delta1
    DNA
    TYPE functioning gene
    STRUCTURE 8.40 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391987 6 similar to Serine palmitoyltransferase 2 (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2) C6orf123 6q27 chromosome 6 open reading frame 123 MLLT4 6q27 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 LOC202546 6q27 hypothetical LOC202546 C6orf54 6q27 chromosome 6 open reading frame 54 KIF25 6q27 kinesin family member 25 FRMD1 6q27 FERM domain containing 1 LOC389450 6 LOC389450 LOC154323 6q27 hypothetical LOC154323 MGC33437 6q27 meningioma expressed antigen 6 (coiled-coil proline-rich) pseudogene DACT2 6q27 dapper homolog 2, antagonist of beta-catenin (xenopus) SMOC2 6q27 SPARC related modular calcium binding 2 LOC346055 6q27 similar to Hypothetical protein CBG10550 THBS2 6q27 thrombospondin 2 LOC391988 6 similar to SPCPB16A4.07c MGC43690 6q27 hypothetical protein MGC43690 PHF10 6q27 PHD finger protein 10 TCTE3 6q27 t-complex-associated-testis-expressed 3 C6orf208 6q27 chromosome 6 open reading frame 208 LOC154449 6q27 hypothetical protein LOC154449 DLL1 6q27 delta-like 1 (Drosophila) KIAA1838 6q27 KIAA1838 PSMB1 7p12 proteasome (prosome, macropain) subunit, beta type, 1 TBP 6q27 TATA box binding protein PDCD2 6q27 programmed cell death 2 LOC391989 6 similar to Olfactory receptor 4F3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3366 - 723 - 2008 18676613
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Digestiveintestinelarge intestinecolon highly
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    Visualeyeanterior segment  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight EGF-like domains
  • one DSL domain
  • a Dll1 intracellular domain (Dll1 icd) that upregulates CTGF promoter activity through both direct and indirect mechanisms
  • HOMOLOGY
    Homologene
    FAMILY
  • delta/serrate/jagged family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text endogenous DLL1 located on the surface of presomitic mesoderm cells
    basic FUNCTION
  • playing a role in mediating cell fate decisions during hematopoiesis and in cell-to-cell communication
  • controls both differentiation of early myoblasts and maintenance of myogenic progenitor cells
  • provides essential signals that are required to prevent uncontrolled differentiation early and ensure sustained muscle differentiation during development
  • play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domain
  • essential regulator of postnatal arteriogenesis (DLL1-mediated Notch activation regulates ephrin-B2 expression and postnatal arteriogenesis)
  • might function as a cis-acting regulatory element that induces undifferentiated cells to become goblet cells
  • DLL1- and DLL4-mediated notch signaling are required for homeostasis of intestinal stem cells
  • implicated in early patterning of the forebrain
  • DLL1 and JAG1 function redundantly and are necessary to maintain the centroacinar cells as an environmental niche in the developing pancreas
  • both NOTCH1 and its ligands DLL1 and JAG1 in B cells promote antibody production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NOTCH receptor ligand
  • implicated in activation of NOTCH (ubiquitination, although not required for endocytosis, is essential for DLL1 recycling and that recycling is required to acquire affinity for the receptor)
  • acting with JAG2 synergistically to regulate hair cell development in the mammalian inner ear
  • interacts with FGF signaling pathway
  • interacting with CTGF (indirect upregulation of CTGF expression by DLL1 is likely due to the ability of Dll1icd to increase Wnt signaling, a pathway that targets CTGF
  • PTF1A-induced DLL1 expression stimulates multipotent pancreatic progenitor cells (MPCs) proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels
  • SYNJ2BP, also known as ARIP2 interacted with the PDZ binding motif of DLL1 and DLL4, but not with the Notch ligand JAG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in adult Down syndrome cortex
    constitutional   deletion    
    in holoprosencephaly
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS