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FLASH GENE
Symbol DLGAP5 contributors: mct - updated : 24-09-2014
HGNC name discs, large (Drosophila) homolog-associated protein 5
HGNC id 16864
Location 14q22.2      Physical location : 55.614.835 - 55.658.396
Synonym name
  • discs, large homolog 7 (Drosophila)
  • hepatoma up-regulated
  • Drosophila discs large-1 tumor supressor-like
  • disks large-associated protein DLG7
  • Synonym symbol(s) HURP, KIAA0008, DLG7, DAP-5, DLG1
    DNA
    TYPE functioning gene
    STRUCTURE 43.56 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3084 - 842 - 2013 23610398
    19 - 2993 - 846 - 2013 23610398
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
     bone marrow  highly
    Connective    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • SAPAP family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localizes to the spindle poles in mitotic cells
  • colocalizes with CDH1 at sites of cell- cell contact in intestinal epithelial cells
  • basic FUNCTION
  • key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells
  • spindle-associated protein that mediates Ran-GTP-dependent assembly of the bipolar spindle and promotes chromosome congression and interkinetochore tension during mitosis
  • affects endometrial stromal proliferation during implantation and specifically, has an essential function in uterine biology
  • is required for the clustering of extra centrosomes before division, arguing for a shared molecular requirement of MT-organizing centers (MTOCs) sorting in mammalian meiosis and cancer cell division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates chromosome congression by modulating kinesin KIF18A function
  • substrate of AURKA, which plays a crucial role in the stabilization of kinetochore fibers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    leading to a more invasive phenotype of hepatocellular carcinoma cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Hurp(-/-) females are completely infertile, whereas the males reproduce normally