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FLASH GENE
Symbol DLGAP3 contributors: mct/npt - updated : 07-11-2009
HGNC name discs, large (Drosophila) homolog-associated protein 3
HGNC id 30368
Location 1p34.3      Physical location : 35.331.037 - 35.370.984
Synonym name
  • SAP90/PSD-95-associated protein 3
  • disks large-associated protein 3
  • SAP90/PSD-95-associated protein 3
  • Synonym symbol(s) SAPAP3, DAP3
    DNA
    TYPE functioning gene
    STRUCTURE 39.95 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3587 106 979 - Bongiorno-Borbone (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PDZ (DHR) domains
  • a SH3 domain
  • a guanylate kinase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SAPAP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • anchoring protein for PTK2 and ASAP1 in post-synaptic densities and may contribute to the synaptic function of these tyrosine kinases (Bongiorno-Borbone 2005)
  • may have a potential activity to maintain the structure of postsynaptic density by concentrating its components to the membrane area (Takeuchi 1997)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PTK2 (residues 676-840) and ASAP1 (Bongiorno-Borbone 2005)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene a promising functional candidate gene for grooming disorders (GDs: pathologic nail biting, pathologic skin picking, and/or trichotillomania) (Bienvenu 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS