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FLASH GENE
Symbol DLGAP2 contributors: mct/npt - updated : 16-02-2010
HGNC name discs, large (Drosophila) homolog-associated protein 2
HGNC id 2906
Location 8p23.3      Physical location : 1.449.568 - 1.656.640
Synonym name
  • PSD-95/SAP90-associated protein-2
  • discs large-associated protein 2
  • Synonym symbol(s) DAP2, GUKAP, SAPAP2, DAP-2
    DNA
    TYPE functioning gene
    STRUCTURE 207.07 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392167 8 similar to Olfactory receptor 4F3 LOC389606 8 similar to bA476I15.3 (novel protein similar to septin) LOC389700 8 similar to bA110H4.2 (similar to membrane protein) LOC392168 8 hypothetical gene supported by AK127000 LOC153561 8 hypothetical protein LOC153561 LOC169270 8p23.3 hypothetical protein LOC169270 LOC392278 8 similar to Rab coupling protein; Rab-interacting recycling protein; Rab effector protein; rab11-family interacting protein 1 FBXO25 8p23.3 F-box only protein 25 LOC392169 8 LOC392169 INM01 8p23.3 hypothetical protein INM01 LOC389607 8 hypothetical gene supported by AK128318 LOC157697 8p23.3 hypothetical protein LOC157697 LOC392170 8 similar to hypothetical protein P1295.15 LOC346910 8p23.3 similar to putative nuclear protein (4B256) LOC392171 8 similar to ENSANGP00000017949 LOC392172 8 similar to hypothetical protein LOC392173 8 similar to Proline-rich protein MP-2 precursor LOC389608 8 LOC389608 LOC392174 8 similar to stage-specific S antigen homolog DLGAP2 8p23 discs, large (Drosophila) homolog-associated protein 2 CLN8 8p23.3 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) LOC286088 8p23.3 similar to TBP-associated factor 15 isoform 1; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kD; TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA box binding protein (TBP)- ARHGEF10 8p23 Rho guanine nucleotide exchange factor (GEF) 10 KIAA0711 8p23.3 Homo sapiens KIAA0711 gene product (KIAA0711), mRNA. LOC392175 8 similar to high molecular weight glutenin subunit x MYOM2 8p23.3 myomesin (M-protein) 2, 165kDa LOC392176 8 similar to proteoglycan core protein, cartilage - bovine (fragments) LOC392177 8 LOC392177 LOC389609 8 hypothetical gene supported by AK128880
    regionally located near the telomere
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 10101 - 975 - Ranta, Takeuchi (1997)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines neuronal cells (PSD)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila discslarge associated protein 2
    intraspecies homolog to DLGAP1
    Homologene
    FAMILY
  • SAPAP family
  • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in synapse organization and neuronal cell signaling
  • may have a potential activity to maintain the structure of postsynaptic density by concentrating its components to the membrane area (Takeuchi 1997)
  • adaptor linking ion channel to the subsynaptic cytoskeleton
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • binding the guanylate kinase-like domains of DLG2,DLG4
  • major constituent of the postsynaptic density (PSD) at the synaptic junction in neuronal cells with DLG2, DLG4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the guanylate kinase-like domains of DLG2, DLG4, DLG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS