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FLASH GENE
Symbol DLG2 contributors: mct - updated : 30-01-2014
HGNC name discs, large homolog 2, chapsyn-110 (Drosophila)
HGNC id 2901
Location 11q14.1      Physical location : 83.166.055 - 85.338.314
Synonym name
  • channel-associated protein of synapses, 110kDa
  • channel-associated protein of synapse-110
  • postsynaptic density protein PSD-93
  • protein phosphatase 1, regulatory subunit 58
  • Synonym symbol(s) PSD-93, chapsyn-110, PPP1R58, PSD93
    DNA
    TYPE functioning gene
    STRUCTURE 2172.26 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D11S901 - D11S4568 - D11S4572 - D11S1365 - D11S4409 - DLG2 /D11S4391 - D11S4634 - D11S4576 - D11S4187 - D11S4135 - qter
    Authors Stathakis (98)
    Physical map
    MGC33846 11q13.5 hypothetical protein MGC33846 LOC143543 11q13.5 similar to Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA binding motif protein, X chromosome) (Glycoprotein p43) PRCP 11q14 prolylcarboxypeptidase (angiotensinase C) FLJ25416 11q13.5 hypothetical protein FLJ25416 LOC390228 11 hypothetical gene supported by AK058145 RAB30 11q12-q14 RAB30, member RAS oncogene family PCF11 11q13 pre-mRNA cleavage complex II protein Pcf11 DKFZp547G183 11q13.5 hypothetical protein DKFZp547G183 FLJ37874 11q13.5-q14.1 hypothetical protein FLJ37874 MDS025 11q14.1 hypothetical protein MDS025 HCP28 11q14.1 cytochrome c, somatic pseudogene FLJ37266 11q14.1 hypothetical protein FLJ37266 DLG2 11q21 discs, large homolog 2, chapsyn-110 (Drosophila) LOC390229 11 similar to HNRPC protein LOC143548 11q14.1 similar to REST corepressor HT007 11q14.1 uncharacterized hypothalamus protein HT007 DKFZp586C1924 11q14.1 hypothetical protein DKFZp586C1924 ZF 11q14 HCF-binding transcription factor Zhangfei FLJ38159 11q14.1 hypothetical protein FLJ38159 SYTL2 11q14 synaptotagmin-like 2 MGC34732 11q14.1 hypothetical protein MGC34732 PICALM 11q14 phosphatidylinositol binding clathrin assembly protein LOC283226 11q14.1 similar to Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (CAAX farnesyltransferase alpha subunit) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase alpha sub EED 11q14.2-q22.3 embryonic ectoderm development HSPC138 11q14.1 hypothetical protein HSPC138 LOC387796 11 LOC387796 FLJ23514 11q14.1 hypothetical protein FLJ23514 ME3 11q21 malic enzyme 3, NADP(+)-dependent, mitochondrial
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 8061 - 975 - 1998 9806853
    23 - 7737 - 870 - 1998 9806853
    PSD93 alpha
    22 - 7730 - 909 - 1998 9806853
    20 - 7096 - 749 - 1998 9806853
    11 - 6138 - 334 - 1998 9806853
    - - - - - - 2004 15304517
  • potentially an important regulator of the spatial and temporal distribution of KCNJ2 channels within neuronal membranes of the central nervous system
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three Dlg (DHR/GLGZ/PDZ) motifs, PDZ1 domain forms a crystallographic trimer that is also predicted to be stable in solution
  • an SH3 domain
  • and a C terminal GUK domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila tumor suppressor gene,discs large (Dlg)
    homolog to rattus Chapsyn-110
    homolog to C.elegans c25f6.2
    intraspecies homolog to sap97 and psd95
    Homologene
    FAMILY MAGUK (membrane-associated guanylate kinase homolog) family of cell junction proteins
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text postsynaptic sites
    basic FUNCTION
  • involved the subcellular targeting of ion channels and glutamate receptors at excitatory synapses
  • appears to mediate tyrosine-phosphorylation of the NMDA receptors and synaptic localization of FYN
  • DLG4, DLG2 and DLG3 are thought to have crucial roles in both AMPA receptor trafficking and formation of NMDA receptor-associated signalling complexes involved in synaptic plasticity
  • might contribute potentially to molecular mechanisms of neuronal damage in brain disorders (brain trauma, seizures, and ischemia)
  • DLG4, DLG3, DLG1, and DLG3 are central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons
  • DLG4 and DLG2 play critical but distinct roles in synaptic scaling up and down
  • scaffolding protein for ionotropic glutamate receptors at excitatory synapses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text small molecule transport
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component heterodimerizing with DLG4 and recruited into the same NMDA receptor and Shaker-type potassium channel clusters
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytoplasmic tail of NMDA receptor subunit
  • potassium channel
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS