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FLASH GENE
Symbol DLEU2 contributors: - updated : 14-06-2006
HGNC name deleted in lymphocytic leukemia, 2
HGNC id 13748
Location 13q14.2-q14.3      Physical location : 50.556.687 - 50.699.677
Synonym name leukemia associated gene 2
Synonym symbol(s) LEUA2, LEU2, BCMSUN, 1B4
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, head to head, opposite orientation
text two EST, LEU3 and LEU4 in the first intron
STRUCTURE 38.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure three alternative 3' ends(exon 8,10,14 )
MAPPING cloned Y linked N status provisional
Map cen - D13S1150 - C13orf1 - RFP2 - KCNRG - DLEU2 - DLEU1 - DLEU7 - RNASEH2B - qter
Authors Ivano (03),Corcoran (04)
Physical map
NUDT15 13q14.12 nudix (nucleoside diphosphate linked moiety X)-type motif 15 VDRIP 13q14.12 vitamin D receptor interacting protein ITM2B 13q14.3 integral membrane protein 2B RB1 13q14.2 retinoblastoma 1 (including osteosarcoma) P2RY5 13q14 purinergic receptor P2Y, G-protein coupled, 5 CHC1L 13q14.3 chromosome condensation 1-like CYSLTR2 13q14.12-p21.1 cysteinyl leukotriene receptor 2 LOC338099 13q13 proteasome activator subunit 2 pseudogene KIAA0970 13q14.11 proteasome activator subunit 2 pseudogene RAD17P2 13q14.3 RAD17 homolog (S. pombe) pseudogene 2 COX7CP1 13q14-q21 cytochrome c oxidase subunit VIIc pseudogene 1 LOC387924 13 similar to hypothetical protein FLJ10826 GPR38 13q14-q21 G protein-coupled receptor 38 CDADC1 13q14.12 cytidine and dCMP deaminase domain containing 1 FLJ12577 13q14.12 hypothetical protein FLJ12577 SETDB2 13q14 SET domain, bifurcated 2 PHF11 13q14.12 PHD finger protein 11 RCBTB1 13q14 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 ARLTS1 EBRP 13q12-q13 emopamil binding related protein, delta8-delta7 sterol isomerase related protein KPNA3 13q14.3 karyopherin alpha 3 (importin alpha 4) LOC220429 13q14.13 similar to Meningioma-expressed antigen 6/11 (MEA6) (MEA11) C13orf1 13q14 chromosome 13 open reading frame 1 RFP2 13q14 ret finger protein 2 KCNRG 13q14.11 potassium channel regulator DLEU2 13q14.2-q14.3 deleted in lymphocytic leukemia, 2 DLEU1 13q14.2-q14.3 deleted in lymphocytic leukemia, 1 FAM10A4 13q14.3 family with sequence similarity 10, member A4 DLEU7 13q14.13 deleted in lymphocytic leukemia 7 FLJ11712 13q14.13 hypothetical protein FLJ11712 GUCY1B2 13q14.3 guanylate cyclase 1, soluble, beta 2 LOC387925 13 LOC387925 LOC341674 13q14.13 similar to ribosomal protein L5; 60S ribosomal protein L5 FLJ30707 13q14.13 hypothetical protein FLJ30707 DDX26 13q14.12-q14.2 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 LOC220433 13q14.13 similar to ribosomal protein S4, X-linked WDFY2 13q14.12 WD repeat and FYVE domain containing 2 FLJ13639 13q14.2 hypothetical protein FLJ13639 FLJ37307 13q14.2 hypothetical protein FLJ37307 DKFZP434K1172 13q14.2 hypothetical protein DKFZp434K1172 LOC387926 13 hypothetical gene supported by AF338231; BC030655 ATP7B 13q14.3 ATPase, Cu++ transporting, beta polypeptide (Wilson disease) KIAA0266 13q12.2-q13.3 KIAA0266 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - splicing 1750 - 84 - Liu
- - - 1400 - - only in thymus and testis Liu
- splicing 1160 10.2 84 - Bullrich
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestivemouthtongue  highly
Endocrineneuroendocrinepituitary  highly
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to murine Dleu2
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION acting as a tumor suppressor
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
and LOH in B cell chronic lymphocytic leukemia (see TSG13B)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS