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FLASH GENE
Symbol DKK4 contributors: mct - updated : 19-01-2017
HGNC name dickkopf homolog 4 (Xenopus laevis)
HGNC id 2894
Location 8p11.21      Physical location : 42.231.586 - 42.234.674
Synonym name inhibitor of WNT signaling,dickkopf 4
DNA
TYPE functioning gene
STRUCTURE 18.13 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Physical map
FLJ13842 8p11.21 hypothetical protein FLJ13842 SFRP1 8p12-p11.2 secreted frizzled-related protein 1 GCP16 LOC392214 8 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC14799 8p11.21 hypothetical protein MGC14799 DKFZp586M1819 8p11.21 putative lysophosphatidic acid acyltransferase FLJ25169 8p11.21 hypothetical protein FLJ25169 ANK1 8p11.2 ankyrin 1, erythrocytic MYST3 8p11 MYST histone acetyltransferase (monocytic leukemia) 3 AP3M2 8p11.2 adaptor-related protein complex 3, mu 2 subunit PLAT 8p12-p11.2 plasminogen activator, tissue LOC389650 8 LOC389650 IKBKB 8p11.2 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta POLB 8p11.2 polymerase (DNA directed), beta DKK4 8p11.2-p11.1 dickkopf homolog 4 (Xenopus laevis) VDAC3 8q11.2 voltage-dependent anion channel 3 SLC20A2 8p12-q21 solute carrier family 20 (phosphate transporter), member 2 LOC114926 8p11.21 hypothetical protein BC013035 CHRNB3 8p11.2 cholinergic receptor, nicotinic, beta polypeptide 3 CHRNA6 8p22 cholinergic receptor, nicotinic, alpha polypeptide 6 THAP1 8p11.1 THAP domain containing, apoptosis associated protein 1 DKFZP564A022 8p11.21 hypothetical protein DKFZp564A022 HOOK3 8p11.21 hook homolog 3 (Drosophila) FNTA 8p22-q11 farnesyltransferase, CAAX box, alpha FLJ23356 8p11.21 hypothetical protein FLJ23356 FLJ32731 8p11.1 hypothetical protein FLJ32731 LOC347028 8p11.21 similar to AFG3-like protein 2 (Paraplegin-like protein) LOC340441 8p11.21 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389651 8 similar to hypothetical protein (L1H 3 region) - human
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 835 - 224 - 2001 11701963
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestiveesophagus    
Nervousbrainhindbraincerebellum  
Respiratorylung    
cell lineage
cell lines
fluid/secretion secreted
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • two clusters of ten cysteine residues separated by a linker region
  • HOMOLOGY
    interspecies ortholog to murine Dkk4
    Homologene
    FAMILY dickkopf family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • acts in a negative feedback loop to attenuate canonical Wnt signaling, and may facilitate a switch to the non-canonical Wnt planar cell polarity (PCP) pathway that is involved in cell movements during morphogenesis
  • acts as a negative regulator of WNT/CTNNB1 pathway
  • DKK1, DKK2, DKK3, DKK4 are known to modulate Wnt/CTNNB1 signaling, which is activated during bone formation
  • functions as an inhibitor of osteoblastogenesis through WNT/CTNNB1 signaling
  • dynamic state of DKK4 itself and its interaction with LRP6 modulates WNT function during Meibomian gland (MG) development, with a novel limitation of DKK4 action by proteolytic cleavage
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    text embryogenesis, morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT proteins
  • LRP6 through the second cluster of cysteine residues
  • cell & other
    REGULATION
    Other unlikely to be involved in holoprosencephaly
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma, associated with CTNNB1 accumulation in hepatocellular carcinoma tissues
    constitutional     --low  
    suppression of DKK4 expression promoted osteoblast proliferation and differentiation and suppressed apoptosis
    tumoral       gain of function
    in most colorectal tumors, and Dickkopf-4 upregulation reflects activation of the Wnt/canonical pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dkk4 transgene in wild-type mice had no effect on primary hair, but secondary hairs were severely malformed